Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

Françoise Borcard, Matthias Baud, Claudia Bello, Giovanna Dal Bello, Francesco Grossi, Paolo Pronzato, Michele Cea, Alessio Nencioni, Pierre Vogel

Research output: Contribution to journalArticlepeer-review

Abstract

New oxathiazinane dioxides derived from d- and l-serine have been tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. Compound (R)-24 (R′ = BrCH2C6H 4-C6H4CH2) showed a cytotoxicity with IC50 ≈ 10 μM.

Original languageEnglish
Pages (from-to)5353-5356
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number17
DOIs
Publication statusPublished - Sep 1 2010

Keywords

  • Benzyl ethers
  • Cancer
  • Cytotoxicity
  • Oxasultams
  • Sultams

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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