Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

Françoise Borcard; Matthias Baud; Claudia Bello; Giovanna Dal Bello; Francesco Grossi; Paolo Pronzato; Michele Cea; Alessio Nencioni; Pierre Vogel

doi:10.1016/j.bmcl.2009.09.019

Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

Françoise Borcard, Matthias Baud, Claudia Bello, Giovanna Dal Bello, Francesco Grossi, Paolo Pronzato, Michele Cea, Alessio Nencioni, Pierre Vogel

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

New oxathiazinane dioxides derived from d- and l-serine have been tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. Compound (R)-24 (R′ = BrCH₂C₆H ₄-C₆H₄CH₂) showed a cytotoxicity with IC₅₀ ≈ 10 μM.

Original language	English
Pages (from-to)	5353-5356
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	20
Issue number	17
DOIs	https://doi.org/10.1016/j.bmcl.2009.09.019
Publication status	Published - Sep 1 2010

Keywords

Benzyl ethers
Cancer
Cytotoxicity
Oxasultams
Sultams

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Organic Chemistry
Molecular Medicine
Molecular Biology
Clinical Biochemistry
Biochemistry

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10.1016/j.bmcl.2009.09.019

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Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity. / Borcard, Françoise; Baud, Matthias; Bello, Claudia; Dal Bello, Giovanna; Grossi, Francesco ; Pronzato, Paolo; Cea, Michele; Nencioni, Alessio; Vogel, Pierre.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 20, No. 17, 01.09.2010, p. 5353-5356.

Research output: Contribution to journal › Article › peer-review

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title = "Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity",

abstract = "New oxathiazinane dioxides derived from d- and l-serine have been tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. Compound (R)-24 (R′ = BrCH2C6H 4-C6H4CH2) showed a cytotoxicity with IC50 ≈ 10 μM.",

keywords = "Benzyl ethers, Cancer, Cytotoxicity, Oxasultams, Sultams",

author = "Fran{\c c}oise Borcard and Matthias Baud and Claudia Bello and {Dal Bello}, Giovanna and Francesco Grossi and Paolo Pronzato and Michele Cea and Alessio Nencioni and Pierre Vogel",

year = "2010",

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AU - Borcard, Françoise

AU - Baud, Matthias

AU - Bello, Claudia

AU - Dal Bello, Giovanna

AU - Grossi, Francesco

AU - Pronzato, Paolo

AU - Cea, Michele

AU - Nencioni, Alessio

AU - Vogel, Pierre

PY - 2010/9/1

Y1 - 2010/9/1

N2 - New oxathiazinane dioxides derived from d- and l-serine have been tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. Compound (R)-24 (R′ = BrCH2C6H 4-C6H4CH2) showed a cytotoxicity with IC50 ≈ 10 μM.

AB - New oxathiazinane dioxides derived from d- and l-serine have been tested for their in vitro cell growth inhibitory activity toward SKBR3 breast cancer cells. Compound (R)-24 (R′ = BrCH2C6H 4-C6H4CH2) showed a cytotoxicity with IC50 ≈ 10 μM.

KW - Benzyl ethers

KW - Cancer

KW - Cytotoxicity

KW - Oxasultams

KW - Sultams

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JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 17

ER -

Synthesis of new oxathiazinane dioxides and their in vitro cancer cell growth inhibitory activity

Abstract

Keywords

ASJC Scopus subject areas

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