Synthesis of novel diazatricyclodecanes (DTDs). Effects of structural variation at the C3′ allyl end and at the phenyl ring of the cinnamyl chain on μ-receptor affinity and opioid antinociception

Gérard Aimè Pinna, Giorgio Cignarella, Stefania Ruiu, Giovanni Loriga, Gabriele Murineddu, Stefania Villa, Giuseppe Enrico Grella, Gregorio Cossu, Walter Fratta

Research output: Contribution to journalArticlepeer-review

Abstract

Two series of analogues of 9-propionyl-10-cinnamyl-9,10-diazatricyclo[4.2.1.12,5]decane (1a) and 2-propionyl-7-cinnamyl-2,7-diazatricyclo[4.4.0.03,8]decane (2a), in which the cinnamyl moiety was replaced by various aralkenyl chains, 1b-l and 2b-l, respectively, have been synthesized and evaluated for their ability to bind to the opioid μ-, δ- and κ-receptors. The binding data indicated that compounds 1b,d,e,h and 2b,d,e,f,h,i showed a μ-affinity in the low nanomolar range with moderate or negligible affinity towards δ- and κ-receptors. Selected DTDs, the pairs 1,2b, 1,2e and 1,2h, were also evaluated for analgesic effect. In the hot plate test, only 1b given ip was found to have similar opioid antinociception and chronic tolerance as morphine.

Original languageEnglish
Pages (from-to)4015-4026
Number of pages12
JournalBioorganic and Medicinal Chemistry
Volume11
Issue number18
DOIs
Publication statusPublished - Sep 1 2003

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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