Synthesis of novel spirostanic saponins and their cytotoxic activity

Juan C. Hernández, Francisco León, Ignacio Brouard, Fernando Torres, Sara Rubio, José Quintana, Francisco Estévez, Jaime Bermejo

Research output: Contribution to journalArticlepeer-review

Abstract

This study was carried out to assess the cytotoxicity of several new synthetic steroidal saponins against the human myeloid leukemia cell lines (HL-60 and U937) and against human melanoma cells (SK-MEL-1). Several diosgenyl glycosides analyzed showed strong cell growth inhibition which was associated with alterations in cell cycle progression and induction of apoptosis. Studies of cytochrome c release and caspase-9 activation suggest a main role of the intrinsic pathway of apoptosis in the mechanism of cytotoxicity caused by this kind of compounds.

Original languageEnglish
Pages (from-to)2063-2076
Number of pages14
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number4
DOIs
Publication statusPublished - Feb 15 2008

Keywords

  • Apoptosis
  • Caspase
  • Cytochrome c release
  • Cytotoxicity
  • Human melanoma cells
  • Leukemia
  • Spirostanic saponins
  • Synthesis

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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