Synthesis of ribosomal proteins in developing Dictyostelium discoideum cells is controlled by the methylation of proteins S24 and S31

Giorgio Mangiarotti, Roberto Giorda

Research output: Contribution to journalArticle

Abstract

Ribosomal protein mRNAs left over from growth are selectively excluded from polyribosomes in the first half of Dictyostelium discoideum development. This is due to the fact that they are sequestered by a class of free 40S ribosomal subunits, characterized by possessing a methylated S24 protein. At the time of formation of tight cell aggregates, the methylated S24 is substituted by an unmethylated S24, while protein S31 of the same or other 40S subunits becomes methylated. This leads to a rapid degradation of the ribosomal protein mRNAs.

Original languageEnglish
Pages (from-to)261-270
Number of pages10
JournalBiochemistry and Cell Biology
Volume80
Issue number2
DOIs
Publication statusPublished - 2002

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Methylation
Dictyostelium
Ribosomal Proteins
Protein Biosynthesis
Eukaryotic Small Ribosome Subunits
Messenger RNA
Polyribosomes
Proteins
Cells
Degradation
Growth

Keywords

  • Dictyostelium
  • Methylation of S24
  • Methylation of S31
  • Synthesis of ribosomal proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

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AB - Ribosomal protein mRNAs left over from growth are selectively excluded from polyribosomes in the first half of Dictyostelium discoideum development. This is due to the fact that they are sequestered by a class of free 40S ribosomal subunits, characterized by possessing a methylated S24 protein. At the time of formation of tight cell aggregates, the methylated S24 is substituted by an unmethylated S24, while protein S31 of the same or other 40S subunits becomes methylated. This leads to a rapid degradation of the ribosomal protein mRNAs.

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