Synthesis of the R and S enantiomers of 1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid

P. Dostert; M. Varasi; A. Della Torre; C. Monti; V. Rizzo

doi:10.1016/0223-5234(92)90061-5

Synthesis of the R and S enantiomers of 1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid

P. Dostert, M. Varasi, A. Della Torre, C. Monti, V. Rizzo

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

1,2,3,4-Tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid (salsolinol-1-carboxylic acid) has been shown to be a bioprecursor of (R)-salsolinol in humans. We report here a synthesis and the determination of the absolute configurations of both enantiomers of salsolinol-1-carboxylic acid.

Original language	English
Pages (from-to)	57-59
Number of pages	3
Journal	European Journal of Medicinal Chemistry
Volume	27
Issue number	1
DOIs	https://doi.org/10.1016/0223-5234(92)90061-5
Publication status	Published - 1992

Keywords

mammalian alkaloids
R and S enantiomers
salsolinol-1-carboxylic acid

ASJC Scopus subject areas

Molecular Medicine
Organic Chemistry
Drug Discovery
Pharmaceutical Science

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10.1016/0223-5234(92)90061-5

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title = "Synthesis of the R and S enantiomers of 1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid",

abstract = "1,2,3,4-Tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid (salsolinol-1-carboxylic acid) has been shown to be a bioprecursor of (R)-salsolinol in humans. We report here a synthesis and the determination of the absolute configurations of both enantiomers of salsolinol-1-carboxylic acid.",

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author = "P. Dostert and M. Varasi and Torre, {A. Della} and C. Monti and V. Rizzo",

year = "1992",

doi = "10.1016/0223-5234(92)90061-5",

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T1 - Synthesis of the R and S enantiomers of 1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid

AU - Dostert, P.

AU - Varasi, M.

AU - Torre, A. Della

AU - Monti, C.

AU - Rizzo, V.

PY - 1992

Y1 - 1992

N2 - 1,2,3,4-Tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid (salsolinol-1-carboxylic acid) has been shown to be a bioprecursor of (R)-salsolinol in humans. We report here a synthesis and the determination of the absolute configurations of both enantiomers of salsolinol-1-carboxylic acid.

AB - 1,2,3,4-Tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid (salsolinol-1-carboxylic acid) has been shown to be a bioprecursor of (R)-salsolinol in humans. We report here a synthesis and the determination of the absolute configurations of both enantiomers of salsolinol-1-carboxylic acid.

KW - mammalian alkaloids

KW - R and S enantiomers

KW - salsolinol-1-carboxylic acid

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