Synthesis of the R and S enantiomers of 1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid

P. Dostert, M. Varasi, A. Della Torre, C. Monti, V. Rizzo

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

1,2,3,4-Tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid (salsolinol-1-carboxylic acid) has been shown to be a bioprecursor of (R)-salsolinol in humans. We report here a synthesis and the determination of the absolute configurations of both enantiomers of salsolinol-1-carboxylic acid.

Original languageEnglish
Pages (from-to)57-59
Number of pages3
JournalEuropean Journal of Medicinal Chemistry
Volume27
Issue number1
DOIs
Publication statusPublished - 1992

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Enantiomers
Carboxylic Acids
Carboxylic acids
1-carboxysalsolinol
1-methylisoquinoline
salsolinol

Keywords

  • mammalian alkaloids
  • R and S enantiomers
  • salsolinol-1-carboxylic acid

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis of the R and S enantiomers of 1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid. / Dostert, P.; Varasi, M.; Torre, A. Della; Monti, C.; Rizzo, V.

In: European Journal of Medicinal Chemistry, Vol. 27, No. 1, 1992, p. 57-59.

Research output: Contribution to journal › Article

Dostert, P, Varasi, M, Torre, AD, Monti, C & Rizzo, V 1992, 'Synthesis of the R and S enantiomers of 1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid', European Journal of Medicinal Chemistry, vol. 27, no. 1, pp. 57-59. https://doi.org/10.1016/0223-5234(92)90061-5
Dostert P, Varasi M, Torre AD, Monti C, Rizzo V. Synthesis of the R and S enantiomers of 1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid. European Journal of Medicinal Chemistry. 1992;27(1):57-59. https://doi.org/10.1016/0223-5234(92)90061-5
Dostert, P. ; Varasi, M. ; Torre, A. Della ; Monti, C. ; Rizzo, V. / Synthesis of the R and S enantiomers of 1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid. In: European Journal of Medicinal Chemistry. 1992 ; Vol. 27, No. 1. pp. 57-59.
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AU - Torre, A. Della

AU - Monti, C.

AU - Rizzo, V.

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