Synthesis of the R and S enantiomers of 1,2,3,4-tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid

P. Dostert, M. Varasi, A. Della Torre, C. Monti, V. Rizzo

Research output: Contribution to journalArticle

Abstract

1,2,3,4-Tetrahydro-6,7-dihydroxy-1-methylisoquinoline-1-carboxylic acid (salsolinol-1-carboxylic acid) has been shown to be a bioprecursor of (R)-salsolinol in humans. We report here a synthesis and the determination of the absolute configurations of both enantiomers of salsolinol-1-carboxylic acid.

Original languageEnglish
Pages (from-to)57-59
Number of pages3
JournalEuropean Journal of Medicinal Chemistry
Volume27
Issue number1
DOIs
Publication statusPublished - 1992

Keywords

  • mammalian alkaloids
  • R and S enantiomers
  • salsolinol-1-carboxylic acid

ASJC Scopus subject areas

  • Molecular Medicine
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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