Synthesis optimization of 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB), β-amyloid PET imaging tracer for Alzheimer's disease diagnosis

A. Coliva, C. Monterisi, A. Apollaro, D. Gatti, M. Penso, L. Gianolli, D. Perani, M. C. Gilardi, A. Carpinelli

Research output: Contribution to journalArticlepeer-review

Abstract

[11C]PIB is the most used amyloid plaques-specific positron-emitting radiotracers. The radiosynthesis of this compound, carried out by methylation of its precursor with [11C]methyl triflate in 2-butanone, has been improved optimizing the initial concentration and the purification method. Two HPLC methods were compared: good radiochemical yields, specific activities, and chemical purity above 98% were achieved by using as eluant acetonitrile/citrate and formulation in 10% ethanol.

Original languageEnglish
Pages (from-to)66-71
Number of pages6
JournalApplied Radiation and Isotopes
Volume105
DOIs
Publication statusPublished - Nov 1 2015

Keywords

  • Alzheimer's disease
  • Cyclotron
  • [11C]MeOTf
  • [11C]PIB
  • β-amyloid

ASJC Scopus subject areas

  • Radiation

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