Synthetic lethality to overcome cancer drug resistance

L. Porcelli; A. E. Quatrale; P. Mantuano; N. Silvestris; A. E. Brunetti; H. Calvert; A. Paradiso; A. Azzariti

doi:10.2174/092986712802002563

Synthetic lethality to overcome cancer drug resistance

L. Porcelli, A. E. Quatrale, P. Mantuano, N. Silvestris, A. E. Brunetti, H. Calvert, A. Paradiso, A. Azzariti

IRCCS Giovanni Paolo II

Research output: Contribution to journal › Article › peer-review

Abstract

A large body of evidence point out that the onset of synthetic lethality may provide a useful tool for amplifying the efficacy of drugs in anticancer regimens, to uncover interdependence between genes and to identify predictive factors that would be extremely useful to guide in the selection of more effective targeted drugs and drug combinations for each patient. Here, we provide an overview on the exploitation of synthetic lethality to overcome drug resistance to conventional chemotherapy in several types of solid tumors. We report recent findings on cellular markers and gene mutations which are specifically essential for the viability of cancer cells and for resistance to chemotherapeutics. In addition, new molecularly targeted strategies to overcome drug resistance are suggested.

Original language	English
Pages (from-to)	3858-3873
Number of pages	16
Journal	Current Medicinal Chemistry
Volume	19
Issue number	23
DOIs	https://doi.org/10.2174/092986712802002563
Publication status	Published - Aug 2012

Keywords

Anticancer therapy
DNA repair pathway
Drug resistance
PARP inhibitors
Solid tumors
Synthetic lethality

ASJC Scopus subject areas

Molecular Medicine
Pharmacology

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AU - Quatrale, A. E.

AU - Mantuano, P.

AU - Silvestris, N.

AU - Brunetti, A. E.

AU - Calvert, H.

AU - Paradiso, A.

AU - Azzariti, A.

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