Abstract
A large body of evidence point out that the onset of synthetic lethality may provide a useful tool for amplifying the efficacy of drugs in anticancer regimens, to uncover interdependence between genes and to identify predictive factors that would be extremely useful to guide in the selection of more effective targeted drugs and drug combinations for each patient. Here, we provide an overview on the exploitation of synthetic lethality to overcome drug resistance to conventional chemotherapy in several types of solid tumors. We report recent findings on cellular markers and gene mutations which are specifically essential for the viability of cancer cells and for resistance to chemotherapeutics. In addition, new molecularly targeted strategies to overcome drug resistance are suggested.
| Original language | English |
|---|---|
| Pages (from-to) | 3858-3873 |
| Number of pages | 16 |
| Journal | Current Medicinal Chemistry |
| Volume | 19 |
| Issue number | 23 |
| DOIs | |
| Publication status | Published - Aug 2012 |
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Keywords
- Anticancer therapy
- DNA repair pathway
- Drug resistance
- PARP inhibitors
- Solid tumors
- Synthetic lethality
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology
Cite this
Synthetic lethality to overcome cancer drug resistance. / Porcelli, L.; Quatrale, A. E.; Mantuano, P.; Silvestris, N.; Brunetti, A. E.; Calvert, H.; Paradiso, A.; Azzariti, A.
In: Current Medicinal Chemistry, Vol. 19, No. 23, 08.2012, p. 3858-3873.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthetic lethality to overcome cancer drug resistance
AU - Porcelli, L.
AU - Quatrale, A. E.
AU - Mantuano, P.
AU - Silvestris, N.
AU - Brunetti, A. E.
AU - Calvert, H.
AU - Paradiso, A.
AU - Azzariti, A.
PY - 2012/8
Y1 - 2012/8
N2 - A large body of evidence point out that the onset of synthetic lethality may provide a useful tool for amplifying the efficacy of drugs in anticancer regimens, to uncover interdependence between genes and to identify predictive factors that would be extremely useful to guide in the selection of more effective targeted drugs and drug combinations for each patient. Here, we provide an overview on the exploitation of synthetic lethality to overcome drug resistance to conventional chemotherapy in several types of solid tumors. We report recent findings on cellular markers and gene mutations which are specifically essential for the viability of cancer cells and for resistance to chemotherapeutics. In addition, new molecularly targeted strategies to overcome drug resistance are suggested.
AB - A large body of evidence point out that the onset of synthetic lethality may provide a useful tool for amplifying the efficacy of drugs in anticancer regimens, to uncover interdependence between genes and to identify predictive factors that would be extremely useful to guide in the selection of more effective targeted drugs and drug combinations for each patient. Here, we provide an overview on the exploitation of synthetic lethality to overcome drug resistance to conventional chemotherapy in several types of solid tumors. We report recent findings on cellular markers and gene mutations which are specifically essential for the viability of cancer cells and for resistance to chemotherapeutics. In addition, new molecularly targeted strategies to overcome drug resistance are suggested.
KW - Anticancer therapy
KW - DNA repair pathway
KW - Drug resistance
KW - PARP inhibitors
KW - Solid tumors
KW - Synthetic lethality
UR - http://www.scopus.com/inward/record.url?scp=84865720100&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84865720100&partnerID=8YFLogxK
U2 - 10.2174/092986712802002563
DO - 10.2174/092986712802002563
M3 - Article
C2 - 22788762
AN - SCOPUS:84865720100
VL - 19
SP - 3858
EP - 3873
JO - Current Medicinal Chemistry
JF - Current Medicinal Chemistry
SN - 0929-8673
IS - 23
ER -