Synthetic lethality to overcome cancer drug resistance

L. Porcelli, A. E. Quatrale, P. Mantuano, N. Silvestris, A. E. Brunetti, H. Calvert, A. Paradiso, A. Azzariti

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A large body of evidence point out that the onset of synthetic lethality may provide a useful tool for amplifying the efficacy of drugs in anticancer regimens, to uncover interdependence between genes and to identify predictive factors that would be extremely useful to guide in the selection of more effective targeted drugs and drug combinations for each patient. Here, we provide an overview on the exploitation of synthetic lethality to overcome drug resistance to conventional chemotherapy in several types of solid tumors. We report recent findings on cellular markers and gene mutations which are specifically essential for the viability of cancer cells and for resistance to chemotherapeutics. In addition, new molecularly targeted strategies to overcome drug resistance are suggested.

Original languageEnglish
Pages (from-to)3858-3873
Number of pages16
JournalCurrent Medicinal Chemistry
Volume19
Issue number23
DOIs
Publication statusPublished - Aug 2012

Fingerprint

Drug Resistance
Drug Combinations
Pharmaceutical Preparations
Genes
Neoplasms
Cell Survival
Drug Therapy
Mutation
Chemotherapy
Tumors
Cells
Synthetic Lethal Mutations

Keywords

  • Anticancer therapy
  • DNA repair pathway
  • Drug resistance
  • PARP inhibitors
  • Solid tumors
  • Synthetic lethality

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Porcelli, L., Quatrale, A. E., Mantuano, P., Silvestris, N., Brunetti, A. E., Calvert, H., ... Azzariti, A. (2012). Synthetic lethality to overcome cancer drug resistance. Current Medicinal Chemistry, 19(23), 3858-3873. https://doi.org/10.2174/092986712802002563

Synthetic lethality to overcome cancer drug resistance. / Porcelli, L.; Quatrale, A. E.; Mantuano, P.; Silvestris, N.; Brunetti, A. E.; Calvert, H.; Paradiso, A.; Azzariti, A.

In: Current Medicinal Chemistry, Vol. 19, No. 23, 08.2012, p. 3858-3873.

Research output: Contribution to journalArticle

Porcelli, L, Quatrale, AE, Mantuano, P, Silvestris, N, Brunetti, AE, Calvert, H, Paradiso, A & Azzariti, A 2012, 'Synthetic lethality to overcome cancer drug resistance', Current Medicinal Chemistry, vol. 19, no. 23, pp. 3858-3873. https://doi.org/10.2174/092986712802002563
Porcelli L, Quatrale AE, Mantuano P, Silvestris N, Brunetti AE, Calvert H et al. Synthetic lethality to overcome cancer drug resistance. Current Medicinal Chemistry. 2012 Aug;19(23):3858-3873. https://doi.org/10.2174/092986712802002563
Porcelli, L. ; Quatrale, A. E. ; Mantuano, P. ; Silvestris, N. ; Brunetti, A. E. ; Calvert, H. ; Paradiso, A. ; Azzariti, A. / Synthetic lethality to overcome cancer drug resistance. In: Current Medicinal Chemistry. 2012 ; Vol. 19, No. 23. pp. 3858-3873.
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