Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions

Alessandro Parodi, Nicoletta Quattrocchi, Anne L. Van De Ven, Ciro Chiappini, Michael Evangelopoulos, Jonathan O. Martinez, Brandon S. Brown, Sm Z. Khaled, Iman K. Yazdi, Maria Vittoria Enzo, Lucas Isenhart, Mauro Ferrari, Ennio Tasciotti

Research output: Contribution to journalArticle

387 Citations (Scopus)

Abstract

The therapeutic efficacy of systemic drug-delivery vehicles depends on their ability to evade the immune system, cross the biological barriers of the body and localize at target tissues. White blood cells of the immune system - known as leukocytes - possess all of these properties and exert their targeting ability through cellular membrane interactions. Here, we show that nanoporous silicon particles can successfully perform all these actions when they are coated with cellular membranes purified from leukocytes. These hybrid particles, called leukolike vectors, can avoid being cleared by the immune system. Furthermore, they can communicate with endothelial cells through receptor-ligand interactions, and transport and release a payload across an inflamed reconstructed endothelium. Moreover, leukolike vectors retained their functions when injected in vivo, showing enhanced circulation time and improved accumulation in a tumour.

Original languageEnglish
Pages (from-to)61-68
Number of pages8
JournalNature Nanotechnology
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 2013

Fingerprint

immune systems
leukocytes
Immune system
biomimetics
Biomimetics
Cell membranes
Nanoparticles
nanoparticles
membranes
endothelium
Membranes
Endothelial cells
Silicon
Drug delivery
payloads
Tumors
delivery
vehicles
drugs
Blood

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Electrical and Electronic Engineering
  • Condensed Matter Physics
  • Atomic and Molecular Physics, and Optics

Cite this

Parodi, A., Quattrocchi, N., Van De Ven, A. L., Chiappini, C., Evangelopoulos, M., Martinez, J. O., ... Tasciotti, E. (2013). Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. Nature Nanotechnology, 8(1), 61-68. https://doi.org/10.1038/nnano.2012.212

Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. / Parodi, Alessandro; Quattrocchi, Nicoletta; Van De Ven, Anne L.; Chiappini, Ciro; Evangelopoulos, Michael; Martinez, Jonathan O.; Brown, Brandon S.; Khaled, Sm Z.; Yazdi, Iman K.; Enzo, Maria Vittoria; Isenhart, Lucas; Ferrari, Mauro; Tasciotti, Ennio.

In: Nature Nanotechnology, Vol. 8, No. 1, 01.2013, p. 61-68.

Research output: Contribution to journalArticle

Parodi, A, Quattrocchi, N, Van De Ven, AL, Chiappini, C, Evangelopoulos, M, Martinez, JO, Brown, BS, Khaled, SZ, Yazdi, IK, Enzo, MV, Isenhart, L, Ferrari, M & Tasciotti, E 2013, 'Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions', Nature Nanotechnology, vol. 8, no. 1, pp. 61-68. https://doi.org/10.1038/nnano.2012.212
Parodi A, Quattrocchi N, Van De Ven AL, Chiappini C, Evangelopoulos M, Martinez JO et al. Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. Nature Nanotechnology. 2013 Jan;8(1):61-68. https://doi.org/10.1038/nnano.2012.212
Parodi, Alessandro ; Quattrocchi, Nicoletta ; Van De Ven, Anne L. ; Chiappini, Ciro ; Evangelopoulos, Michael ; Martinez, Jonathan O. ; Brown, Brandon S. ; Khaled, Sm Z. ; Yazdi, Iman K. ; Enzo, Maria Vittoria ; Isenhart, Lucas ; Ferrari, Mauro ; Tasciotti, Ennio. / Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions. In: Nature Nanotechnology. 2013 ; Vol. 8, No. 1. pp. 61-68.
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