Synthetic peptides containing a conserved sequence motif of the Id protein family modulate vascular smooth muscle cell phenotype

Sara Pellegrino, Nicola Ferri, Noemi Colombo, Edoardo Cremona, Alberto Corsini, Roberto Fanelli, Maria Luisa Gelmi, Chiara Cabrele

Research output: Contribution to journalArticlepeer-review

Abstract

Modulation of smooth muscle cells to a proliferating and migrating phenotype with downregulated α-actin expression is observed upon vascular lesion formation. The Id proteins (inhibitors of cell differentiation) play a role in the development of this phenotype. In contrast, synthetic peptides based on a conserved 11-residue Id sequence trigger the switch to a contractile phenotype that shows reduced cell growth and migration, increased expression of α-actin and decreased Id protein levels.

Original languageEnglish
Pages (from-to)6298-6302
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number22
DOIs
Publication statusPublished - 2009

Keywords

  • Helix-loop-helix
  • Id proteins
  • Peptide dimerization
  • Peptide mimic
  • Protein domain recognition
  • Smooth muscle cell
  • Solid-phase peptide synthesis

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

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