Abstract
Preclinical models suggest that refinoids inhibit mammary carcinogenesis. The induction of apoptosis is a unique feature of fenretinide, the most-studied retinoid in clinical trials of breast cancer chemoprevention, owing to its selective accumulation in breast tissue and its favorable toxicological profile. In a Phase III breast cancer prevention trial, fenretinide showed a strong trend of reduction of incidence of second breast malignancies in premenopausal women, which was confirmed by 15 years of follow-up. This warrants further research on the mechanisms of action and potential efficacy of fenrefinide and provides the rationale for a Phase III primary prevention trial in young women at high risk for breast cancer. This review will highlight the role of fenrefinide in breast cancer chemoprevention.
Original language | English |
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Pages (from-to) | 423-432 |
Number of pages | 10 |
Journal | Expert Review of Anticancer Therapy |
Volume | 7 |
Issue number | 4 |
DOIs | |
Publication status | Published - Apr 2007 |
Keywords
- Breast neoplasm
- Chemoprevention
- Clinical trial
- Fenretinide
- Retinoid
ASJC Scopus subject areas
- Cancer Research
- Pharmacology