Systematic analysis of mouse genome reveals distinct evolutionary and functional properties among circadian and ultradian genes

Stefano Castellana, Tommaso Mazza, Daniele Capocefalo, Nikolai Genov, Tommaso Biagini, Caterina Fusilli, Felix Scholkmann, Angela Relógio, John B. Hogenesch, Gianluigi Mazzoccoli

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In living organisms, biological clocks regulate 24 h (circadian) molecular, physiological, and behavioral rhythms to maintain homeostasis and synchrony with predictable environmental changes, in particular with those induced by Earth's rotation on its axis. Harmonics of these circadian rhythms having periods of 8 and 12 h (ultradian) have been documented in several species. In mouse liver, harmonics of the 24-h period of gene transcription hallmarked genes oscillating with a frequency two or three times faster than circadian periodicity. Many of these harmonic transcripts enriched pathways regulating responses to environmental stress and coinciding preferentially with subjective dawn and dusk. At this time, the evolutionary history of genes with rhythmic expression is still poorly known and the role of length-of-day changes due to Earth's rotation speed decrease over the last four billion years is totally ignored. We hypothesized that ultradian and stress anticipatory genes would be more evolutionarily conserved than circadian genes and background non-oscillating genes. To investigate this issue, we performed broad computational analyses of genes/proteins oscillating at different frequency ranges across several species and showed that ultradian genes/proteins, especially those oscillating with a 12-h periodicity, are more likely to be of ancient origin and essential in mice. In summary, our results show that genes with ultradian transcriptional patterns are more likely to be phylogenetically conserved and associated with the primeval and inevitable dawn/dusk transitions.

Original languageEnglish
Article number1178
JournalFrontiers in Physiology
Volume9
Issue numberAUG
DOIs
Publication statusPublished - Aug 23 2018

Fingerprint

Genome
Genes
Periodicity
Biological Clocks
Circadian Rhythm
Proteins
Homeostasis
History
Liver

Keywords

  • Circadian
  • Clock
  • Evolution
  • Gene
  • Rhythmicity
  • Ultradian

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Systematic analysis of mouse genome reveals distinct evolutionary and functional properties among circadian and ultradian genes. / Castellana, Stefano; Mazza, Tommaso; Capocefalo, Daniele; Genov, Nikolai; Biagini, Tommaso; Fusilli, Caterina; Scholkmann, Felix; Relógio, Angela; Hogenesch, John B.; Mazzoccoli, Gianluigi.

In: Frontiers in Physiology, Vol. 9, No. AUG, 1178, 23.08.2018.

Research output: Contribution to journalArticle

@article{420e1eca963641c9b3a3c80a4fb2b497,
title = "Systematic analysis of mouse genome reveals distinct evolutionary and functional properties among circadian and ultradian genes",
abstract = "In living organisms, biological clocks regulate 24 h (circadian) molecular, physiological, and behavioral rhythms to maintain homeostasis and synchrony with predictable environmental changes, in particular with those induced by Earth's rotation on its axis. Harmonics of these circadian rhythms having periods of 8 and 12 h (ultradian) have been documented in several species. In mouse liver, harmonics of the 24-h period of gene transcription hallmarked genes oscillating with a frequency two or three times faster than circadian periodicity. Many of these harmonic transcripts enriched pathways regulating responses to environmental stress and coinciding preferentially with subjective dawn and dusk. At this time, the evolutionary history of genes with rhythmic expression is still poorly known and the role of length-of-day changes due to Earth's rotation speed decrease over the last four billion years is totally ignored. We hypothesized that ultradian and stress anticipatory genes would be more evolutionarily conserved than circadian genes and background non-oscillating genes. To investigate this issue, we performed broad computational analyses of genes/proteins oscillating at different frequency ranges across several species and showed that ultradian genes/proteins, especially those oscillating with a 12-h periodicity, are more likely to be of ancient origin and essential in mice. In summary, our results show that genes with ultradian transcriptional patterns are more likely to be phylogenetically conserved and associated with the primeval and inevitable dawn/dusk transitions.",
keywords = "Circadian, Clock, Evolution, Gene, Rhythmicity, Ultradian",
author = "Stefano Castellana and Tommaso Mazza and Daniele Capocefalo and Nikolai Genov and Tommaso Biagini and Caterina Fusilli and Felix Scholkmann and Angela Rel{\'o}gio and Hogenesch, {John B.} and Gianluigi Mazzoccoli",
year = "2018",
month = "8",
day = "23",
doi = "10.3389/fphys.2018.01178",
language = "English",
volume = "9",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Research Foundation",
number = "AUG",

}

TY - JOUR

T1 - Systematic analysis of mouse genome reveals distinct evolutionary and functional properties among circadian and ultradian genes

AU - Castellana, Stefano

AU - Mazza, Tommaso

AU - Capocefalo, Daniele

AU - Genov, Nikolai

AU - Biagini, Tommaso

AU - Fusilli, Caterina

AU - Scholkmann, Felix

AU - Relógio, Angela

AU - Hogenesch, John B.

AU - Mazzoccoli, Gianluigi

PY - 2018/8/23

Y1 - 2018/8/23

N2 - In living organisms, biological clocks regulate 24 h (circadian) molecular, physiological, and behavioral rhythms to maintain homeostasis and synchrony with predictable environmental changes, in particular with those induced by Earth's rotation on its axis. Harmonics of these circadian rhythms having periods of 8 and 12 h (ultradian) have been documented in several species. In mouse liver, harmonics of the 24-h period of gene transcription hallmarked genes oscillating with a frequency two or three times faster than circadian periodicity. Many of these harmonic transcripts enriched pathways regulating responses to environmental stress and coinciding preferentially with subjective dawn and dusk. At this time, the evolutionary history of genes with rhythmic expression is still poorly known and the role of length-of-day changes due to Earth's rotation speed decrease over the last four billion years is totally ignored. We hypothesized that ultradian and stress anticipatory genes would be more evolutionarily conserved than circadian genes and background non-oscillating genes. To investigate this issue, we performed broad computational analyses of genes/proteins oscillating at different frequency ranges across several species and showed that ultradian genes/proteins, especially those oscillating with a 12-h periodicity, are more likely to be of ancient origin and essential in mice. In summary, our results show that genes with ultradian transcriptional patterns are more likely to be phylogenetically conserved and associated with the primeval and inevitable dawn/dusk transitions.

AB - In living organisms, biological clocks regulate 24 h (circadian) molecular, physiological, and behavioral rhythms to maintain homeostasis and synchrony with predictable environmental changes, in particular with those induced by Earth's rotation on its axis. Harmonics of these circadian rhythms having periods of 8 and 12 h (ultradian) have been documented in several species. In mouse liver, harmonics of the 24-h period of gene transcription hallmarked genes oscillating with a frequency two or three times faster than circadian periodicity. Many of these harmonic transcripts enriched pathways regulating responses to environmental stress and coinciding preferentially with subjective dawn and dusk. At this time, the evolutionary history of genes with rhythmic expression is still poorly known and the role of length-of-day changes due to Earth's rotation speed decrease over the last four billion years is totally ignored. We hypothesized that ultradian and stress anticipatory genes would be more evolutionarily conserved than circadian genes and background non-oscillating genes. To investigate this issue, we performed broad computational analyses of genes/proteins oscillating at different frequency ranges across several species and showed that ultradian genes/proteins, especially those oscillating with a 12-h periodicity, are more likely to be of ancient origin and essential in mice. In summary, our results show that genes with ultradian transcriptional patterns are more likely to be phylogenetically conserved and associated with the primeval and inevitable dawn/dusk transitions.

KW - Circadian

KW - Clock

KW - Evolution

KW - Gene

KW - Rhythmicity

KW - Ultradian

UR - http://www.scopus.com/inward/record.url?scp=85052054046&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85052054046&partnerID=8YFLogxK

U2 - 10.3389/fphys.2018.01178

DO - 10.3389/fphys.2018.01178

M3 - Article

AN - SCOPUS:85052054046

VL - 9

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

IS - AUG

M1 - 1178

ER -