Systematic lymphadenectomy in ovarian cancer at second-look surgery: A randomised clinical trial

T. Dell Anna, M. Signorelli, P. Benedetti-Panici, A. Maggioni, R. Fossati, R. Fruscio, R. Milani, L. Bocciolone, A. Buda, C. Mangioni, G. Scambia, R. Angioli, E. Campagnutta, R. Grassi, F. Landoni

Research output: Contribution to journalArticlepeer-review

Abstract

Background:The role of systematic aortic and pelvic lymphadenectomy (SAPL) at second-look surgery in early stage or optimally debulked advanced ovarian cancer is unclear and never addressed by randomised studies.Methods:From January 1991 through May 2001, 308 patients with the International Federation of Gynaecology and Obstetrics stage IA-IV epithelial ovarian carcinoma were randomly assigned to undergo SAPL (n=158) or resection of bulky nodes only (n=150). Primary end point was overall survival (OS).Results:The median operating time, blood loss, percentage of patients requiring blood transfusions and hospital stay were higher in the SAPL than in the control arm (P

Original languageEnglish
Pages (from-to)785-792
Number of pages8
JournalBritish Journal of Cancer
Volume107
Issue number5
DOIs
Publication statusPublished - Aug 21 2012

Keywords

  • lymphadenectomy
  • ovarian cancer
  • second-look surgery

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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