TY - JOUR
T1 - Systematic lymphadenectomy in ovarian cancer at second-look surgery
T2 - A randomised clinical trial
AU - Dell Anna, T.
AU - Signorelli, M.
AU - Benedetti-Panici, P.
AU - Maggioni, A.
AU - Fossati, R.
AU - Fruscio, R.
AU - Milani, R.
AU - Bocciolone, L.
AU - Buda, A.
AU - Mangioni, C.
AU - Scambia, G.
AU - Angioli, R.
AU - Campagnutta, E.
AU - Grassi, R.
AU - Landoni, F.
PY - 2012/8/21
Y1 - 2012/8/21
N2 - Background:The role of systematic aortic and pelvic lymphadenectomy (SAPL) at second-look surgery in early stage or optimally debulked advanced ovarian cancer is unclear and never addressed by randomised studies.Methods:From January 1991 through May 2001, 308 patients with the International Federation of Gynaecology and Obstetrics stage IA-IV epithelial ovarian carcinoma were randomly assigned to undergo SAPL (n=158) or resection of bulky nodes only (n=150). Primary end point was overall survival (OS).Results:The median operating time, blood loss, percentage of patients requiring blood transfusions and hospital stay were higher in the SAPL than in the control arm (P
AB - Background:The role of systematic aortic and pelvic lymphadenectomy (SAPL) at second-look surgery in early stage or optimally debulked advanced ovarian cancer is unclear and never addressed by randomised studies.Methods:From January 1991 through May 2001, 308 patients with the International Federation of Gynaecology and Obstetrics stage IA-IV epithelial ovarian carcinoma were randomly assigned to undergo SAPL (n=158) or resection of bulky nodes only (n=150). Primary end point was overall survival (OS).Results:The median operating time, blood loss, percentage of patients requiring blood transfusions and hospital stay were higher in the SAPL than in the control arm (P
KW - lymphadenectomy
KW - ovarian cancer
KW - second-look surgery
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U2 - 10.1038/bjc.2012.336
DO - 10.1038/bjc.2012.336
M3 - Article
C2 - 22864456
AN - SCOPUS:84865414048
VL - 107
SP - 785
EP - 792
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 5
ER -