Systematic Review and Meta-Analysis-Is there a Benefit in Using Neoadjuvant Systemic Chemotherapy for Locally Advanced Penile Squamous Cell Carcinoma?

Mounsif Azizi, Ahmet M. Aydin, Ali Hajiran, Andrew Lai, Ambuj Kumar, Charles C. Peyton, Suks Minhas, Guru P. Sonpavde, Jad Chahoud, Lance C. Pagliaro, Andrea Necchi, Philippe E. Spiess

Research output: Contribution to journalArticlepeer-review

Abstract

PURPOSE: Neoadjuvant chemotherapy is a recommended treatment for patients with penile cancer with bulky inguinal lymphadenopathy or unresectable primary tumors, although there is no evidence of its benefit from randomized trials. MATERIALS AND METHODS: We conducted a systematic search in Embase® and MEDLINE® for studies reporting on patients who received preoperative neoadjuvant chemotherapy for locally advanced penile squamous cell carcinoma. Objective response rate, pathological complete response, grade 3 or greater toxicity and overall mortality were evaluated in terms of neoadjuvant chemotherapy type, which was dichotomized as nontaxane-platinum and taxane-platinum regimens. RESULTS: Overall 10 studies met the inclusion criteria, enrolling a total of 182 patients, with 66 (36.3 and 116 (63.7 treated with nontaxane-platinum and taxane-platinum regimens, respectively. The pooled results demonstrated an objective response rate of 53952-64), pathological complete response rate of 16 grade 3 or greater toxicity rate of 40959-64) and overall mortality of 55950-70) in patients treated with neoadjuvant chemotherapy. Stratified subanalysis revealed an objective response rate of 559 a pathological complete response of 90 a toxicity rate of 269 and an overall mortality of 548platinum vs taxane-platinum regimens, respectively. CONCLUSIONS: The pooled findings in this study suggest that approximately 506 or greater adverse events (269. Ultimately the robustness of these observations should be interpreted with an awareness of the inherent limitations of deriving data from a collection of small, heterogeneous series.
Original languageEnglish
JournalJournal of Urology
Issue number6
Publication statusPublished - Jun 1 2020

Fingerprint Dive into the research topics of 'Systematic Review and Meta-Analysis-Is there a Benefit in Using Neoadjuvant Systemic Chemotherapy for Locally Advanced Penile Squamous Cell Carcinoma?'. Together they form a unique fingerprint.

Cite this