Systematic review and meta-analysis of perioperative outcomes and complications after robot-assisted radical prostatectomy

Giacomo Novara, Vincenzo Ficarra, Raymond C. Rosen, Walter Artibani, Anthony Costello, James A. Eastham, Markus Graefen, Giorgio Guazzoni, Shahrokh F. Shariat, Jens Uwe Stolzenburg, Hendrik Van Poppel, Filiberto Zattoni, Francesco Montorsi, Alexandre Mottrie, Timothy G. Wilson

Research output: Contribution to journalArticle

251 Citations (Scopus)

Abstract

Context: Perioperative complications are a major surgical outcome for radical prostatectomy (RP). Objective: Evaluate complication rates following robot-assisted RP (RARP), risk factors for complications after RARP, and surgical techniques to improve complication rates after RARP. We also performed a cumulative analysis of all studies comparing RARP with retropubic RP (RRP) or laparoscopic RP (LRP) in terms of perioperative complications. Evidence acquisition: A systematic review of the literature was performed in August 2011, searching Medline, Embase, and Web of Science databases. A free-text protocol using the term radical prostatectomy was applied. The following limits were used: humans; gender (male); and publications dating from January 1, 2008. A cumulative analysis was conducted using Review Manager software v.4.2 (Cochrane Collaboration, Oxford, UK). Evidence synthesis: We retrieved 110 papers evaluating oncologic outcomes following RARP. Overall mean operative time is 152 min; mean blood loss is 166 ml; mean transfusion rate is 2%; mean catheterization time is 6.3 d; and mean in-hospital stay is 1.9 d. The mean complication rate was 9%, with most of the complications being of low grade. Lymphocele/lymphorrea (3.1%), urine leak (1.8%), and reoperation (1.6%) are the most prevalent surgical complications. Blood loss (weighted mean difference: 582.77; p <0.00001) and transfusion rate (odds ratio [OR]: 7.55; p <0.00001) were lower in RARP than in RRP, whereas only transfusion rate (OR: 2.56; p = 0.005) was lower in RARP than in LRP. All the other analyzed parameters were similar, regardless of the surgical approach. Conclusions: RARP can be performed routinely with a relatively small risk of complications. Surgical experience, clinical patient characteristics, and cancer characteristics may affect the risk of complications. Cumulative analyses demonstrated that blood loss and transfusion rates were significantly lower with RARP than with RRP, and transfusion rates were lower with RARP than with LRP, although all other features were similar regardless of the surgical approach.

Original languageEnglish
Pages (from-to)431-452
Number of pages22
JournalEuropean Urology
Volume62
Issue number3
DOIs
Publication statusPublished - Sep 2012

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Prostatectomy
Meta-Analysis
Odds Ratio
Lymphocele
Operative Time
Reoperation
Catheterization
Blood Transfusion
Publications
Length of Stay
Software
Urine
Databases
Neoplasms

Keywords

  • Laparoscopy
  • Prostatectomy
  • Prostatic neoplasms
  • Robotics

ASJC Scopus subject areas

  • Urology

Cite this

Novara, G., Ficarra, V., Rosen, R. C., Artibani, W., Costello, A., Eastham, J. A., ... Wilson, T. G. (2012). Systematic review and meta-analysis of perioperative outcomes and complications after robot-assisted radical prostatectomy. European Urology, 62(3), 431-452. https://doi.org/10.1016/j.eururo.2012.05.044

Systematic review and meta-analysis of perioperative outcomes and complications after robot-assisted radical prostatectomy. / Novara, Giacomo; Ficarra, Vincenzo; Rosen, Raymond C.; Artibani, Walter; Costello, Anthony; Eastham, James A.; Graefen, Markus; Guazzoni, Giorgio; Shariat, Shahrokh F.; Stolzenburg, Jens Uwe; Van Poppel, Hendrik; Zattoni, Filiberto; Montorsi, Francesco; Mottrie, Alexandre; Wilson, Timothy G.

In: European Urology, Vol. 62, No. 3, 09.2012, p. 431-452.

Research output: Contribution to journalArticle

Novara, G, Ficarra, V, Rosen, RC, Artibani, W, Costello, A, Eastham, JA, Graefen, M, Guazzoni, G, Shariat, SF, Stolzenburg, JU, Van Poppel, H, Zattoni, F, Montorsi, F, Mottrie, A & Wilson, TG 2012, 'Systematic review and meta-analysis of perioperative outcomes and complications after robot-assisted radical prostatectomy', European Urology, vol. 62, no. 3, pp. 431-452. https://doi.org/10.1016/j.eururo.2012.05.044
Novara, Giacomo ; Ficarra, Vincenzo ; Rosen, Raymond C. ; Artibani, Walter ; Costello, Anthony ; Eastham, James A. ; Graefen, Markus ; Guazzoni, Giorgio ; Shariat, Shahrokh F. ; Stolzenburg, Jens Uwe ; Van Poppel, Hendrik ; Zattoni, Filiberto ; Montorsi, Francesco ; Mottrie, Alexandre ; Wilson, Timothy G. / Systematic review and meta-analysis of perioperative outcomes and complications after robot-assisted radical prostatectomy. In: European Urology. 2012 ; Vol. 62, No. 3. pp. 431-452.
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AU - Costello, Anthony

AU - Eastham, James A.

AU - Graefen, Markus

AU - Guazzoni, Giorgio

AU - Shariat, Shahrokh F.

AU - Stolzenburg, Jens Uwe

AU - Van Poppel, Hendrik

AU - Zattoni, Filiberto

AU - Montorsi, Francesco

AU - Mottrie, Alexandre

AU - Wilson, Timothy G.

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N2 - Context: Perioperative complications are a major surgical outcome for radical prostatectomy (RP). Objective: Evaluate complication rates following robot-assisted RP (RARP), risk factors for complications after RARP, and surgical techniques to improve complication rates after RARP. We also performed a cumulative analysis of all studies comparing RARP with retropubic RP (RRP) or laparoscopic RP (LRP) in terms of perioperative complications. Evidence acquisition: A systematic review of the literature was performed in August 2011, searching Medline, Embase, and Web of Science databases. A free-text protocol using the term radical prostatectomy was applied. The following limits were used: humans; gender (male); and publications dating from January 1, 2008. A cumulative analysis was conducted using Review Manager software v.4.2 (Cochrane Collaboration, Oxford, UK). Evidence synthesis: We retrieved 110 papers evaluating oncologic outcomes following RARP. Overall mean operative time is 152 min; mean blood loss is 166 ml; mean transfusion rate is 2%; mean catheterization time is 6.3 d; and mean in-hospital stay is 1.9 d. The mean complication rate was 9%, with most of the complications being of low grade. Lymphocele/lymphorrea (3.1%), urine leak (1.8%), and reoperation (1.6%) are the most prevalent surgical complications. Blood loss (weighted mean difference: 582.77; p <0.00001) and transfusion rate (odds ratio [OR]: 7.55; p <0.00001) were lower in RARP than in RRP, whereas only transfusion rate (OR: 2.56; p = 0.005) was lower in RARP than in LRP. All the other analyzed parameters were similar, regardless of the surgical approach. Conclusions: RARP can be performed routinely with a relatively small risk of complications. Surgical experience, clinical patient characteristics, and cancer characteristics may affect the risk of complications. Cumulative analyses demonstrated that blood loss and transfusion rates were significantly lower with RARP than with RRP, and transfusion rates were lower with RARP than with LRP, although all other features were similar regardless of the surgical approach.

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