TY - JOUR
T1 - Systematic review and meta-analysis of randomized controlled trials evaluating silodosin in the treatment of non-neurogenic male lower urinary tract symptoms suggestive of benign prostatic enlargement
AU - Novara, Giacomo
AU - Tubaro, Andrea
AU - Sanseverino, Roberto
AU - Spatafora, Sebastiano
AU - Artibani, Walter
AU - Zattoni, Filiberto
AU - Montorsi, Francesco
AU - Chapple, Christopher R.
PY - 2013/8
Y1 - 2013/8
N2 - Purpose: To perform a systematic review and meta-analysis of randomized clinical trials (RCTs) reporting the efficacy and safety of silodosin in the treatment of non-neurogenic male LUTS suggestive of benign prostatic enlargement. Patients and methods: A systematic review searching multiple dataset for the term "silodosin". A meta-analysis was conducted using Review Manager software (Cochrane Collaboration, Oxford, UK). Results: Our systematic search retrieved four studies summarizing the data of five RCTs. Silodosin was more effective than placebo with regard to mean change in all the parameters related to the IPSS and Qmax (all p values max (p ≤ 0.05). Silodosin and tamsulosin 0.4 mg were similarly effective in all the efficacy analyses. AEj was less common with tamsulosin 0.2 and 0.4 mg (p values
AB - Purpose: To perform a systematic review and meta-analysis of randomized clinical trials (RCTs) reporting the efficacy and safety of silodosin in the treatment of non-neurogenic male LUTS suggestive of benign prostatic enlargement. Patients and methods: A systematic review searching multiple dataset for the term "silodosin". A meta-analysis was conducted using Review Manager software (Cochrane Collaboration, Oxford, UK). Results: Our systematic search retrieved four studies summarizing the data of five RCTs. Silodosin was more effective than placebo with regard to mean change in all the parameters related to the IPSS and Qmax (all p values max (p ≤ 0.05). Silodosin and tamsulosin 0.4 mg were similarly effective in all the efficacy analyses. AEj was less common with tamsulosin 0.2 and 0.4 mg (p values
KW - α-Blockers
KW - Benign prostatic enlargement
KW - Male lower urinary tract symptoms
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U2 - 10.1007/s00345-012-0944-8
DO - 10.1007/s00345-012-0944-8
M3 - Article
C2 - 23053207
AN - SCOPUS:84881053758
VL - 31
SP - 997
EP - 1008
JO - World Journal of Urology
JF - World Journal of Urology
SN - 0724-4983
IS - 4
ER -