Systematic review and meta-analysis of randomized controlled trials evaluating silodosin in the treatment of non-neurogenic male lower urinary tract symptoms suggestive of benign prostatic enlargement

Giacomo Novara, Andrea Tubaro, Roberto Sanseverino, Sebastiano Spatafora, Walter Artibani, Filiberto Zattoni, Francesco Montorsi, Christopher R. Chapple

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To perform a systematic review and meta-analysis of randomized clinical trials (RCTs) reporting the efficacy and safety of silodosin in the treatment of non-neurogenic male LUTS suggestive of benign prostatic enlargement. Patients and methods: A systematic review searching multiple dataset for the term "silodosin". A meta-analysis was conducted using Review Manager software (Cochrane Collaboration, Oxford, UK). Results: Our systematic search retrieved four studies summarizing the data of five RCTs. Silodosin was more effective than placebo with regard to mean change in all the parameters related to the IPSS and Qmax (all p values max (p ≤ 0.05). Silodosin and tamsulosin 0.4 mg were similarly effective in all the efficacy analyses. AEj was less common with tamsulosin 0.2 and 0.4 mg (p values

Original languageEnglish
Pages (from-to)997-1008
Number of pages12
JournalWorld Journal of Urology
Volume31
Issue number4
DOIs
Publication statusPublished - Aug 2013

Keywords

  • α-Blockers
  • Benign prostatic enlargement
  • Male lower urinary tract symptoms

ASJC Scopus subject areas

  • Urology

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