Systematic Review and Meta-analysis of SNPs from Genome-Wide Association Studies of Head and Neck Cancer

Vladimir Vukovic, Jovana Stojanovic, Alessia Vecchioni, Roberta Pastorino, Stefania Boccia

Research output: Contribution to journalReview articlepeer-review


Objective: Various genome-wide association studies (GWASs) identified new head and neck cancer (HNC) susceptibility loci, although the evidence has not been systematically summarized. We performed a systematic review and meta-analyses of the GWASs to identify the most commonly reported genetic loci associated with a risk of HNC. Data Sources: We searched the PubMed, ISI Web of Science, SCOPUS, and GWAS databases to retrieve eligible studies, in English or Italian, published until June 1, 2017. Review Methods: Only GWASs reporting data on the association between single-nucleotide polymorphisms (SNPs) and HNC were included. The quality of included studies was evaluated using the Q-Genie tool. Random-effect meta-analyses were performed considering only SNPs with at least 1 significant result from the included articles, and pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results: Seven studies of case-control design were included in the review. Five studies on nasopharyngeal cancer (NPC) in Chinese, reporting on 27 different SNPs, were included in meta-analyses. Results show that 6 SNPs (rs2076483, rs2975042, rs9258122, rs29232, and rs9510787) had an increased pooled estimates for A risk alleles (OR [95% CI]: 1.55 [1.36-1.77], 1.90 [1.69-2.14], 1.47 [1.31-1.65], 1.52 [1.32-1.76], and 1.22 [1.13-1.31], respectively) while G risk allele of rs3129055 reported an OR of 1.49 (95% CI, 1.33-1.67). Conclusion: Our systematic review identified 5 SNPs located on chromosome 6 (rs2076483, rs2975042, rs3129055, rs9258122, and rs29232) and 1 (rs9510787) on chromosome 13 as significantly associated with an increased risk of NPC in Chinese.

Original languageEnglish
Pages (from-to)615-624
Number of pages10
JournalOtolaryngology - Head and Neck Surgery (United States)
Issue number4
Publication statusPublished - Oct 1 2018


  • genetic loci
  • genomics
  • head and neck cancer
  • meta-analysis
  • SNP

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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