TY - JOUR
T1 - Systematic review of 2008-2012 literature and update of recommendations for the use of methotrexate in rheumatic diseases, with a focus on rheumatoid arthritis
AU - Todoerti, M.
AU - Maglione, W.
AU - Bernero, E.
AU - Bortoluzzi, A.
AU - Colaci, M.
AU - Galuppi, E.
AU - Paolino, S.
AU - Talarico, R.
AU - Cutolo, M.
AU - Ferri, C.
AU - Trotta, F.
AU - Bombardieri, S.
AU - Maurizio Montecucco, C.
AU - Sinigaglia, L.
PY - 2013
Y1 - 2013
N2 - The objective of this review is to update the recommendations of the 2010 Italian Consensus on the use of methotrexate (MTX) in rheumatoid arthritis (RA) and other rheumatic diseases. The literature published between 2008 and 2012 was systematically reviewed and updated recommendations on MTX use in rheumatic diseases, particularly RA, were formulated. These recommendations were approved by a panel of expert Italian Rheumatologists. A total of 10,238 references were identified, among which 70 studies were selected for critical evaluation. Sufficient evidence had accumulated to warrant changes to several of the recommendations in the new version. A new recommendation for patients with RA who are in MTX-induced clinical remission was also proposed and approved by the panel. Updated recommendations for the use of MTX in patients with RA or other rheumatologic disease are proposed.
AB - The objective of this review is to update the recommendations of the 2010 Italian Consensus on the use of methotrexate (MTX) in rheumatoid arthritis (RA) and other rheumatic diseases. The literature published between 2008 and 2012 was systematically reviewed and updated recommendations on MTX use in rheumatic diseases, particularly RA, were formulated. These recommendations were approved by a panel of expert Italian Rheumatologists. A total of 10,238 references were identified, among which 70 studies were selected for critical evaluation. Sufficient evidence had accumulated to warrant changes to several of the recommendations in the new version. A new recommendation for patients with RA who are in MTX-induced clinical remission was also proposed and approved by the panel. Updated recommendations for the use of MTX in patients with RA or other rheumatologic disease are proposed.
KW - Evidence-based medicine
KW - Methotrexate
KW - Recommendations
KW - Rheumatic diseases
KW - Rheumatoid arthritis
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U2 - 10.4081/reumatismo.2013.207
DO - 10.4081/reumatismo.2013.207
M3 - Article
C2 - 24399184
AN - SCOPUS:84890842060
VL - 65
SP - 207
EP - 218
JO - Reumatismo
JF - Reumatismo
SN - 0048-7449
IS - 5
ER -