Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies

Mariangela Garofalo, Alessandro Villa, Nicoletta Rizzi, Lukasz Kuryk, Vincenzo Mazzaferro, Paolo Ciana

Research output: Contribution to journalArticle

Abstract

Oncolytic viruses (OV) are engineered to infect, replicate in and kill cancer cells. Currently, the OV therapeutic approach is mainly restricted to neoplasia amenable to direct local administration of viral particles, while the possibility of a systemic delivery of cancer-tropic viruses would extend the OV application to the treatment of metastatic neoplasia. Herein, we applied in vivo/ex vivo imaging to demonstrate that cancer tropism is achieved when OV are encapsulated inside extracellular vesicles (EV) administered intravenously (i.v.), but not when injected intraperitoneally (i.p.). Moreover, we show that the therapeutic procedure adopted does not alter the immunomodulatory properties of the viruses.

Original languageEnglish
JournalViruses
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 13 2018

Keywords

  • Adenoviridae/chemistry
  • Animals
  • Extracellular Vesicles/metabolism
  • Humans
  • Lung Neoplasms/immunology
  • Mice
  • Mice, Inbred C57BL
  • Oncolytic Virotherapy
  • Oncolytic Viruses/chemistry

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