Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice

S. Astigiano, A. Puglisi, L. Mastracci, S. Fais, O. Barbieri

Research output: Contribution to journalArticlepeer-review

Abstract

The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), oral administration of alkaline water was devoid of unwanted side effects, and when started from an early age was as effective as NaHCO3 in significantly delaying tumour progression, while when started when prostate tumours were already present, a nonstatistically significant trend in the same direction was detected. These findings indicate that the use of alkalinizing drugs should be considered for chemoprevention and, in association with standard chemotherapy, for treatment of human prostate AC. © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Original languageEnglish
Pages (from-to)363-368
Number of pages6
JournalJournal of Enzyme Inhibition and Medicinal Chemistry
Volume32
Issue number1
DOIs
Publication statusPublished - 2017

Keywords

  • Alkalinisation
  • chemoprevention
  • prostate tumour
  • TRAMP mice
  • tumour microenvironment
  • alkaline water
  • alkalinizing agent
  • antineoplastic agent
  • bicarbonate
  • unclassified drug
  • water
  • death receptor 3
  • Tnfrsf25 protein, mouse
  • alkalinization
  • animal experiment
  • animal model
  • Article
  • cancer incidence
  • comparative study
  • controlled study
  • female
  • gait
  • histology
  • human
  • human cell
  • hydronephrosis
  • immunohistochemistry
  • mouse
  • nonhuman
  • pH
  • priority journal
  • prostate adenocarcinoma
  • T lymphocyte
  • tramp c1 cell line
  • TRAMP-C2 cell line
  • tumor growth
  • tumor xenograft
  • animal
  • C57BL mouse
  • genetics
  • male
  • pathology
  • prostate tumor
  • transgenic mouse
  • tumor cell line
  • tumor microenvironment
  • Animals
  • Cell Line, Tumor
  • Hydrogen-Ion Concentration
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Prostatic Neoplasms
  • Receptors, Tumor Necrosis Factor, Member 25
  • Tumor Microenvironment

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