Systemic and cellular consequences of macrophage control of iron metabolism

S. Recalcati, M. Locati, G. Cairo

Research output: Contribution to journalArticle

Abstract

Iron is necessary for both mammalian cells and microorganisms, which fiercely compete for this essential nutrient. Accordingly, macrophages exploit the denial of iron from microbial pathogens as an important strategy to accomplish their key role in innate immunity and host defense. Macrophages employ multiple mechanisms to accumulate iron and thus contain microbial infections, but this may come at a price. In particular, at the systemic level iron sequestration in the reticuloendothelial cells can lead to the development of anemia of chronic disease. At the local level, iron sequestration in macrophages, which is targeted to extracellular invaders, can in turn favor intracellular pathogens. Moreover, iron accumulation can per se promote pro-inflammatory activation of macrophages and consequently contribute to maintain the process of inflammation, without resolution. Finally, the peculiar iron trafficking that characterizes alternatively polarized macrophages can influence neighboring cells in the microenvironment and impact on the resolution phase of inflammation. In this review, we describe the role of macrophages in iron metabolism in the context of host defense and iron balance.

Original languageEnglish
Pages (from-to)393-398
Number of pages6
JournalSeminars in Immunology
Volume24
Issue number6
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Inflammation
  • Iron
  • Macrophages
  • Pathogens

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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