Systemic and local haemodinamic and metabolic findings after sub-total hepatectomy in the pig

F. Uggeri, R. Chiesa, G. Bragherio

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Abstract

We studied the haemodynamic changes and those of the splanchnic area and the changes in biochemical parameters as well as those of bloods gases in 8 pigs after 70% hepatectomy. Immediately after the operation the pressure in the portal vein increased by 30%, without significant changes in systemic arterial pressure. During the post-operative course there was a fleeting rise of bilirubin, alkaline phosphatase, SGOT and SGPT and a fall of blood pH up to the 48th hour. The systemic arteriovenous oxygen difference showed a constant rise. Tests done at 48 hours after operation showed progressive normalisation of systemic and splanchnic pressure values as well as metabolic values. The haemodynamic changes and some initial biochemical parameters are due to the sudden loss of liver tissue, anoxia due to stasis of the residual hepatic parenchyma and venous stasis in the splanchnic area. The return of these values to normal after the operations was due to normalisation of the splanchnic circulation effected by perfusion to full capacitance of the residual liver tissue and the reservoir function of the spleen. As a confirmation of this we were never able to demonstrate a collateral porto-systemic circulation by means of angiography.

Original languageEnglish
Pages (from-to)307-314
Number of pages8
JournalSurgery in Italy
Volume7
Issue number4
Publication statusPublished - 1977

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ASJC Scopus subject areas

  • Medicine(all)

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