TY - JOUR
T1 - Systemic chemotherapy for advanced rare pancreatic histotype tumors
AU - Brunetti, Oronzo
AU - Aprile, Giuseppe
AU - Marchetti, Paolo
AU - Vasile, Enrico
AU - Casadei Gardini, Andrea
AU - Scartozzi, Mario
AU - Barni, Sandro
AU - Delfanti, Sara
AU - De Vita, Fernando
AU - Di Costanzo, Francesco
AU - Milella, Michele
AU - Cella, Chiara Alessandra
AU - Berardi, Rossana
AU - Cataldo, Ivana
AU - Scarpa, Aldo
AU - Basile, Debora
AU - Mazzuca, Federica
AU - Graziano, Giusi
AU - Argentiero, Antonella
AU - Santini, Daniele
AU - Reni, Michele
AU - Cascinu, Stefano
AU - Silvestris, Nicola
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Objectives Two issues were put forth by clinicians in the management of the advanced stages of rare variants of pancreatic ductal adenocarcinoma and other exocrine histotypes with peculiar clinical and pathological features: Do chemotherapy regimens recommended in pancreatic ductal adenocarcinoma patients have a clinical activity in rare pancreatic tumors? Or should other chemotherapy combinations be considered in this subset of patients? Methods We conducted a multicenter retrospective study that collected data from 2005 to 2016 at 14 Italian cancer centers with the aim to evaluate tumor response and time to progression for first- and second-line and overall survival. Results Of approximately 4300 exocrine pancreatic cancer patients, 79 advanced cases affected by rare histological types were identified, with pancreatic acinar cell cancer (n = 23), pancreatic adenosquamous cancer (n = 16), and mucinous cystic neoplasm with an associated invasive mucinous cystadenocarcinoma (n = 15) most represented. Survival analyses for each subgroup in relation with the different chemotherapy regimens showed the lack of statistical significance correlations. Conclusions Because of the lack of clinical trials in patients affected by these rare pancreatic histotypes, only their molecular classification would help clinicians in future therapeutic choice.
AB - Objectives Two issues were put forth by clinicians in the management of the advanced stages of rare variants of pancreatic ductal adenocarcinoma and other exocrine histotypes with peculiar clinical and pathological features: Do chemotherapy regimens recommended in pancreatic ductal adenocarcinoma patients have a clinical activity in rare pancreatic tumors? Or should other chemotherapy combinations be considered in this subset of patients? Methods We conducted a multicenter retrospective study that collected data from 2005 to 2016 at 14 Italian cancer centers with the aim to evaluate tumor response and time to progression for first- and second-line and overall survival. Results Of approximately 4300 exocrine pancreatic cancer patients, 79 advanced cases affected by rare histological types were identified, with pancreatic acinar cell cancer (n = 23), pancreatic adenosquamous cancer (n = 16), and mucinous cystic neoplasm with an associated invasive mucinous cystadenocarcinoma (n = 15) most represented. Survival analyses for each subgroup in relation with the different chemotherapy regimens showed the lack of statistical significance correlations. Conclusions Because of the lack of clinical trials in patients affected by these rare pancreatic histotypes, only their molecular classification would help clinicians in future therapeutic choice.
KW - mucinous cystadenocarcinoma
KW - pancreatic acinar cell cancer
KW - pancreatic adenosquamous cancer
KW - rare pancreatic tumor
U2 - 10.1097/MPA.0000000000001063
DO - 10.1097/MPA.0000000000001063
M3 - Articolo
VL - 47
SP - 759
EP - 771
JO - Pancreas
JF - Pancreas
SN - 0885-3177
IS - 6
ER -