Systemic chemotherapy in combination with pericardial window has better outcomes in malignant pericardial effusions

Sezai Çelik, Chiara Lestuzzi, Eugenio Cervesato, Didier Dequanter, Patrizia Piotti, Marzia De Biasio, Massimo Imazio

Research output: Contribution to journalArticlepeer-review


Methods Patients treated with systemic CT alone (Group A), CT plus drainage (Group B), or CT plus pericardial window (Group C) were included. Treatment response was defined as complete response (ie, no more pericardial effusion or masses), partial response (ie, reduced total score, without requiring further treatments), stable disease (ie, unchanged total score), or progressive disease (ie, increased total score). Patients with partial or complete response were considered responders.

Results This preliminary report included 175 patients (56.6% male) with a mean age of 54.21 ± 14.26 years. Gender distribution, age, and follow-up duration was similar for all groups (P >.05). Prevalent cancer types were lung cancer (50.9%), breast cancer (14.9%), and lymphoma/leukemia (14.9%). Overall, 22.3%, 42.9%, and 34.9% of patients were in treatment group A, B, and C, respectively. There were 132 responders (75.3%). The rate of responders significantly differed between groups (P

Conclusions Systemic CT plus pericardial window is a more effective treatment option compared with systemic CT alone and systemic CT plus drainage in patients with malignant effusions.

Objective Our aim was to compare systemic chemotherapy (CT) with drainage and with pericardial window in the treatment of neoplastic pericarditis in patients with various malignancies included in the International Neoplastic Pericarditis Treatment study.

Original languageEnglish
Pages (from-to)2288-2293
Number of pages6
JournalJournal of Thoracic and Cardiovascular Surgery
Issue number5
Publication statusPublished - Nov 1 2014

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine
  • Medicine(all)


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