Systemic features of immune recognition in the gut

Bartlomiej Swiatczak, Maria Rescigno, Irun R. Cohen

Research output: Contribution to journalArticle

Abstract

The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.

Original languageEnglish
Pages (from-to)983-991
Number of pages9
JournalMicrobes and Infection
Volume13
Issue number12-13
DOIs
Publication statusPublished - Nov 2011

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Keywords

  • Immune recognition
  • Pathogen
  • Pathogen-associated molecular pattern
  • Systems immunology

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases

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