Abstract
The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.
| Original language | English |
|---|---|
| Pages (from-to) | 983-991 |
| Number of pages | 9 |
| Journal | Microbes and Infection |
| Volume | 13 |
| Issue number | 12-13 |
| DOIs | |
| Publication status | Published - Nov 2011 |
Fingerprint
Keywords
- Immune recognition
- Pathogen
- Pathogen-associated molecular pattern
- Systems immunology
ASJC Scopus subject areas
- Microbiology
- Immunology
- Infectious Diseases
Cite this
Systemic features of immune recognition in the gut. / Swiatczak, Bartlomiej; Rescigno, Maria; Cohen, Irun R.
In: Microbes and Infection, Vol. 13, No. 12-13, 11.2011, p. 983-991.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Systemic features of immune recognition in the gut
AU - Swiatczak, Bartlomiej
AU - Rescigno, Maria
AU - Cohen, Irun R.
PY - 2011/11
Y1 - 2011/11
N2 - The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.
AB - The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.
KW - Immune recognition
KW - Pathogen
KW - Pathogen-associated molecular pattern
KW - Systems immunology
UR - http://www.scopus.com/inward/record.url?scp=80053384489&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80053384489&partnerID=8YFLogxK
U2 - 10.1016/j.micinf.2011.06.011
DO - 10.1016/j.micinf.2011.06.011
M3 - Article
VL - 13
SP - 983
EP - 991
JO - Microbes and Infection
JF - Microbes and Infection
SN - 1286-4579
IS - 12-13
ER -