Systemic features of immune recognition in the gut

Bartlomiej Swiatczak; Maria Rescigno; Irun R. Cohen

doi:10.1016/j.micinf.2011.06.011

Systemic features of immune recognition in the gut

Bartlomiej Swiatczak, Maria Rescigno, Irun R. Cohen

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article › peer-review

Abstract

The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.

Original language	English
Pages (from-to)	983-991
Number of pages	9
Journal	Microbes and Infection
Volume	13
Issue number	12-13
DOIs	https://doi.org/10.1016/j.micinf.2011.06.011
Publication status	Published - Nov 2011

Keywords

Immune recognition
Pathogen
Pathogen-associated molecular pattern
Systems immunology

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/j.micinf.2011.06.011

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AU - Rescigno, Maria

AU - Cohen, Irun R.

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AB - The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.

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KW - Pathogen-associated molecular pattern

KW - Systems immunology

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Systemic features of immune recognition in the gut

Abstract

Keywords

ASJC Scopus subject areas

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