Systemic gene therapy with anti-angiogenic factors inhibits spontaneous breast tumor growth and metastasis in MMTVneu transgenic mice

M. G. Sacco, E. Mira Catò, R. Ceruti, S. Soldati, S. Indraccolo, M. Caniatti, E. Scanziani, P. Vezzoni

Research output: Contribution to journalArticle

Abstract

Tumor growth and metastasis are angiogenesis-dependent. The possibility of inhibiting tumor growth by interfering with the formation of new vessels has recently raised considerable interest. We previously reported that it is possible to inhibit primary tumor growth and metastasis in a transgenic model of spontaneous breast tumor, which shows many similarities to its human counterpart (including ability to metastasize) by intratumoral administration of a DNA construct carrying the murine angiostatin cDNA driven by liposomes. Here we report that it is also possible to achieve this goal by a systemic (intraperitoneal) delivery of therapeutic DNA constructs carrying genes coding for mouse and human anti-angiogenic factors which include angiostatin, endostatin and TIMP-2. These findings may be relevant to the design of therapeutic interventions in humans.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalGene Therapy
Volume8
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Anti-angiogenesis
  • Breast adenocarcinoma
  • Gene therapy
  • Liposomes
  • Metastasis
  • Transgenic mice

ASJC Scopus subject areas

  • Genetics

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