Systemic impact of breast reconstruction

Giuseppe Curigliano, Janaina Brollo, Maximiliano Cassilha Kneubil

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Normal wound repair generates an angiogenic response to deliver nutrients and inflammatory cells to injured tissue. The angiogenic response facilitates the removal of debris and is central to the development of a granulation tissue framework for wound closure. The mediators of wound angiogenesis include soluble factors such as vascular endothelial growth factor, tumor necrosis factor, transforming growth factor β, basic fibroblast growth factor, and platelet-derived growth factor, which have been identified in several wound models. Angiogenic agonists (e.g., vascular endothelial growth factor) and antagonists (e.g., thrombospondin-1) have been described at various times during repair, suggesting that the neoangiogenic stimulus may be a balance of factors changing to favor either vessel growth or vessel regression. It has been suggested that the inflammatory cells and cytokines found in tumors are more likely to contribute to tumor growth, progression, and immunosuppression than they are to mount an effective host antitumor response. Patients undergoing major oncological resections might develop cytokine production dysregulation and subsequent postsurgical immunosuppression, especially when the operation is of long duration. The balance between proangiogenic and antiangiogenic factors should be investigated.

Original languageEnglish
Title of host publicationOncoplastic and Reconstructive Breast Surgery
PublisherSpringer-Verlag Italia s.r.l.
Pages417-421
Number of pages5
ISBN (Print)9788847026520, 9788847026513
DOIs
Publication statusPublished - Jan 1 2013

Fingerprint

Mammaplasty
Vascular Endothelial Growth Factor A
Wounds and Injuries
Immunosuppression
Cytokines
Thrombospondin 1
Granulation Tissue
Platelet-Derived Growth Factor
Transforming Growth Factors
Fibroblast Growth Factor 2
Growth
Neoplasms
Tumor Necrosis Factor-alpha
Food

Keywords

  • Adipocyte
  • Angiogenesis
  • Breast reconstruction
  • Endothelial cells
  • Endothelial progenitors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Curigliano, G., Brollo, J., & Cassilha Kneubil, M. (2013). Systemic impact of breast reconstruction. In Oncoplastic and Reconstructive Breast Surgery (pp. 417-421). Springer-Verlag Italia s.r.l.. https://doi.org/10.1007/978-88-470-2652-0_45

Systemic impact of breast reconstruction. / Curigliano, Giuseppe; Brollo, Janaina; Cassilha Kneubil, Maximiliano.

Oncoplastic and Reconstructive Breast Surgery. Springer-Verlag Italia s.r.l., 2013. p. 417-421.

Research output: Chapter in Book/Report/Conference proceedingChapter

Curigliano, G, Brollo, J & Cassilha Kneubil, M 2013, Systemic impact of breast reconstruction. in Oncoplastic and Reconstructive Breast Surgery. Springer-Verlag Italia s.r.l., pp. 417-421. https://doi.org/10.1007/978-88-470-2652-0_45
Curigliano G, Brollo J, Cassilha Kneubil M. Systemic impact of breast reconstruction. In Oncoplastic and Reconstructive Breast Surgery. Springer-Verlag Italia s.r.l. 2013. p. 417-421 https://doi.org/10.1007/978-88-470-2652-0_45
Curigliano, Giuseppe ; Brollo, Janaina ; Cassilha Kneubil, Maximiliano. / Systemic impact of breast reconstruction. Oncoplastic and Reconstructive Breast Surgery. Springer-Verlag Italia s.r.l., 2013. pp. 417-421
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