Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis

Research output: Contribution to journalArticle

Abstract

Objective: To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive "lone" hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage. Methods:Sera were obtained from a total of 99 patients with HOA (52 patients with erosive HOA and 47 patients with non-erosive HOA) and from 50 control subjects (NC). Hand radiographs were obtained from all patients and scored for joint damage according to the Kellgren-Lawrence and the Kailman scores. Serum levels of high-sensitivity CRP (hsCRP), IL-6, pentraxin-3 (PTX-3), anti-CCP and anti-modified citrullinated vimentin (MCV) antibodies were evaluated by a sandwich ELISA. Results: Circulating levels of inflammatory biomarkers hsCRP, IL-6 and PTX3 were not significantly different in the two groups of patients with erosive and non-erosive HOA compared to NC and no significant difference was seen between non-erosive and erosive HOA. Anti-CCP positivity was detected respectively in I patient (2.1%) with non-erosive HOA and 1 patient (1.9%) with erosive HOA. Anti-MCV antibodies were present in 4 patients (8.5%) with non-erosive HOA, and 4 patients (7.7%) with erosive HOA. In the control group, one subject (2%) was positive for anti-CCP and 2 subjects (4%) had and-MCV antibodies. Significant correlation was obtained only between body mass index and hsCRP concentration (r=0.4071; p

Original languageEnglish
Pages (from-to)1006-1009
Number of pages4
JournalClinical and Experimental Rheumatology
Volume29
Issue number6
Publication statusPublished - 2011

Keywords

  • Citrullinated antibodies
  • Osteoathritis
  • Systemic inflammation

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

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