Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis

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11 Citations (Scopus)

Abstract

Objective: To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive "lone" hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage. Methods:Sera were obtained from a total of 99 patients with HOA (52 patients with erosive HOA and 47 patients with non-erosive HOA) and from 50 control subjects (NC). Hand radiographs were obtained from all patients and scored for joint damage according to the Kellgren-Lawrence and the Kailman scores. Serum levels of high-sensitivity CRP (hsCRP), IL-6, pentraxin-3 (PTX-3), anti-CCP and anti-modified citrullinated vimentin (MCV) antibodies were evaluated by a sandwich ELISA. Results: Circulating levels of inflammatory biomarkers hsCRP, IL-6 and PTX3 were not significantly different in the two groups of patients with erosive and non-erosive HOA compared to NC and no significant difference was seen between non-erosive and erosive HOA. Anti-CCP positivity was detected respectively in I patient (2.1%) with non-erosive HOA and 1 patient (1.9%) with erosive HOA. Anti-MCV antibodies were present in 4 patients (8.5%) with non-erosive HOA, and 4 patients (7.7%) with erosive HOA. In the control group, one subject (2%) was positive for anti-CCP and 2 subjects (4%) had and-MCV antibodies. Significant correlation was obtained only between body mass index and hsCRP concentration (r=0.4071; p

Original languageEnglish
Pages (from-to)1006-1009
Number of pages4
JournalClinical and Experimental Rheumatology
Volume29
Issue number6
Publication statusPublished - 2011

Fingerprint

Osteoarthritis
Hand
Inflammation
Peptides
Antibodies
Vimentin
Interleukin-6
Serum
Autoimmunity
Hip
Knee
Body Mass Index
Joints
Biomarkers
Enzyme-Linked Immunosorbent Assay
Control Groups

Keywords

  • Citrullinated antibodies
  • Osteoathritis
  • Systemic inflammation

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

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title = "Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis",
abstract = "Objective: To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive {"}lone{"} hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage. Methods:Sera were obtained from a total of 99 patients with HOA (52 patients with erosive HOA and 47 patients with non-erosive HOA) and from 50 control subjects (NC). Hand radiographs were obtained from all patients and scored for joint damage according to the Kellgren-Lawrence and the Kailman scores. Serum levels of high-sensitivity CRP (hsCRP), IL-6, pentraxin-3 (PTX-3), anti-CCP and anti-modified citrullinated vimentin (MCV) antibodies were evaluated by a sandwich ELISA. Results: Circulating levels of inflammatory biomarkers hsCRP, IL-6 and PTX3 were not significantly different in the two groups of patients with erosive and non-erosive HOA compared to NC and no significant difference was seen between non-erosive and erosive HOA. Anti-CCP positivity was detected respectively in I patient (2.1{\%}) with non-erosive HOA and 1 patient (1.9{\%}) with erosive HOA. Anti-MCV antibodies were present in 4 patients (8.5{\%}) with non-erosive HOA, and 4 patients (7.7{\%}) with erosive HOA. In the control group, one subject (2{\%}) was positive for anti-CCP and 2 subjects (4{\%}) had and-MCV antibodies. Significant correlation was obtained only between body mass index and hsCRP concentration (r=0.4071; p",
keywords = "Citrullinated antibodies, Osteoathritis, Systemic inflammation",
author = "Paolo Dolzani and Elisa Assirelli and Lia Pulsatelli and Olga Addimanda and Luana Mancarella and Giuseppe Peri and Alberto Mantovani and Andrea Facchini and Riccardo Meliconi",
year = "2011",
language = "English",
volume = "29",
pages = "1006--1009",
journal = "Clinical and Experimental Rheumatology",
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TY - JOUR

T1 - Systemic inflammation and antibodies to citrullinated peptides in hand osteoarthritis

AU - Dolzani, Paolo

AU - Assirelli, Elisa

AU - Pulsatelli, Lia

AU - Addimanda, Olga

AU - Mancarella, Luana

AU - Peri, Giuseppe

AU - Mantovani, Alberto

AU - Facchini, Andrea

AU - Meliconi, Riccardo

PY - 2011

Y1 - 2011

N2 - Objective: To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive "lone" hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage. Methods:Sera were obtained from a total of 99 patients with HOA (52 patients with erosive HOA and 47 patients with non-erosive HOA) and from 50 control subjects (NC). Hand radiographs were obtained from all patients and scored for joint damage according to the Kellgren-Lawrence and the Kailman scores. Serum levels of high-sensitivity CRP (hsCRP), IL-6, pentraxin-3 (PTX-3), anti-CCP and anti-modified citrullinated vimentin (MCV) antibodies were evaluated by a sandwich ELISA. Results: Circulating levels of inflammatory biomarkers hsCRP, IL-6 and PTX3 were not significantly different in the two groups of patients with erosive and non-erosive HOA compared to NC and no significant difference was seen between non-erosive and erosive HOA. Anti-CCP positivity was detected respectively in I patient (2.1%) with non-erosive HOA and 1 patient (1.9%) with erosive HOA. Anti-MCV antibodies were present in 4 patients (8.5%) with non-erosive HOA, and 4 patients (7.7%) with erosive HOA. In the control group, one subject (2%) was positive for anti-CCP and 2 subjects (4%) had and-MCV antibodies. Significant correlation was obtained only between body mass index and hsCRP concentration (r=0.4071; p

AB - Objective: To investigate systemic inflammation and autoimmune response to citrullinated peptides in patients with erosive and non erosive "lone" hand osteoarthritis (HOA) with no hip/knee involvement and their relationship with radiographic structural damage. Methods:Sera were obtained from a total of 99 patients with HOA (52 patients with erosive HOA and 47 patients with non-erosive HOA) and from 50 control subjects (NC). Hand radiographs were obtained from all patients and scored for joint damage according to the Kellgren-Lawrence and the Kailman scores. Serum levels of high-sensitivity CRP (hsCRP), IL-6, pentraxin-3 (PTX-3), anti-CCP and anti-modified citrullinated vimentin (MCV) antibodies were evaluated by a sandwich ELISA. Results: Circulating levels of inflammatory biomarkers hsCRP, IL-6 and PTX3 were not significantly different in the two groups of patients with erosive and non-erosive HOA compared to NC and no significant difference was seen between non-erosive and erosive HOA. Anti-CCP positivity was detected respectively in I patient (2.1%) with non-erosive HOA and 1 patient (1.9%) with erosive HOA. Anti-MCV antibodies were present in 4 patients (8.5%) with non-erosive HOA, and 4 patients (7.7%) with erosive HOA. In the control group, one subject (2%) was positive for anti-CCP and 2 subjects (4%) had and-MCV antibodies. Significant correlation was obtained only between body mass index and hsCRP concentration (r=0.4071; p

KW - Citrullinated antibodies

KW - Osteoathritis

KW - Systemic inflammation

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M3 - Article

VL - 29

SP - 1006

EP - 1009

JO - Clinical and Experimental Rheumatology

JF - Clinical and Experimental Rheumatology

SN - 0392-856X

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ER -