Systemic Inflammation Is Associated with Oncological Outcome in Patients with High-Grade Myxofibrosarcoma of the Extremities: A Retrospective Analysis

Andrea Sambri, Riccardo Zucchini, Claudio Giannini, Luca Cevolani, Michele Fiore, Paolo Spinnato, Giuseppe Bianchi, Davide Maria Donati, Massimiliano De Paolis

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: The aim of this retrospective study is to verify whether preoperative systemic inflammatory markers (serum C-reactive protein [CRP] and neutrophil-lymphocyte ratio [NLR]) can help in predicting the disease-specific survival (DSS) and local recurrence (LR) rate in adult patients affected by localized myxofibrosarcoma (MFS) of the extremities.

METHODS: We reviewed 126 adult patients with primary, localized MFS of the limbs. We analyzed DSS and LR.

RESULTS: Median age at the time of surgery was 68 years (range 19-92). Median CRP was 0.4 mg/dL and median NLR was 2.8. A worse DSS was found in patients who had preoperative CRP >0.5 mg/dL (p = 0.002) and in those with NLR >3.5 (p < 0.001). In multivariate analysis, tumor size and grade as well as preoperative CRP values and NLR were confirmed to be prognostic factors in terms of DSS. An increased risk of LR was found in multivariate analysis in patients with a tail sign and with high gadolinium enhancement at preoperative MRI.

CONCLUSIONS: Patients with high preoperative CRP and NLR levels, as well as large and high-grade tumors, might be considered as candidates for additional, more aggressive treatment approaches or more stringent follow-up schedules.

Original languageEnglish
Pages (from-to)531-538
Number of pages8
JournalOncology Research and Treatment
Volume43
Issue number10
Early online dateAug 18 2020
DOIs
Publication statusPublished - 2020

Keywords

  • C-reactive protein
  • Grade
  • Inflammation
  • Myxofibrosarcoma
  • Prognosis

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