Systemic inflammation, nutritional status and tumor immune microenvironment determine outcome of resected non-small cell lung cancer

Marco Alifano, Audrey Mansuet-Lupo, Filippo Lococo, Nicolas Roche, Antonio Bobbio, Emelyne Canny, Olivier Schussler, Hervé Dermine, Jean François Régnard, Barbara Burroni, Jérémy Goc, Jérôme Biton, Hanane Ouakrim, Isabelle Cremer, Marie Caroline Dieu-Nosjean, Diane Damotte

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Hypothesizing that nutritional status, systemic inflammation and tumoral immune microenvironment play a role as determinants of lung cancer evolution, the purpose of this study was to assess their respective impact on long-term survival in resected non-small cell lung cancers (NSCLC).

Methods and Findings: Clinical, pathological and laboratory data of 303 patients surgically treated for NSCLC were retrospectively analyzed. C-reactive protein (CRP) and prealbumin levels were recorded, and tumoral infiltration by CD8+ lymphocytes and mature dendritic cells was assessed. We observed that factors related to nutritional status, systemic inflammation and tumoral immune microenvironment were correlated; significant correlations were also found between these factors and other relevant clinical-pathological parameters. With respect to outcome, at univariate analysis we found statistically significant associations between survival and the following variables: Karnofsky index, American Society of Anesthesiologists (ASA) class, CRP levels, prealbumin concentrations, extent of resection, pathologic stage, pT and pN parameters, presence of vascular emboli, and tumoral infiltration by either CD8+ lymphocytes or mature dendritic cells and, among adenocarcinoma type, tumor grade (all p

Conclusions: Our data show that nutrition, systemic inflammation and tumoral immune contexture are prognostic determinants that, taken together, may predict outcome.

Original languageEnglish
Article numbere106914
JournalPLoS One
Volume9
Issue number9
DOIs
Publication statusPublished - Sep 19 2014

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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