Systemic Inflammatory Response Is a Prognostic Marker in HIV-Infected Patients with Hepatocellular Carcinoma

DJ Pinato, Marco Merli, A Dalla Pria, S Jamshaid, K Parker, N Pagani, H Hasson, C Uberti Foppa, Emanuela Messina, R Sharma, M Nelson, M Bower

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Abstract

Background: Hepatocellular carcinoma (HCC) is increasingly prevalent in people living with HIV. Systemic inflammation is a prognostic factor requiring validation in HIV-associated HCC. Aims: Using a multi-centre database of consecutive HCC cases, we investigated the prognostic role of a panel of inflammatory markers, including neutrophil to lymphocyte ratio (NLR), using univariate and multivariate survival analyses. Results: Fifty-nine patients with HIV-associated HCC secondary to hepatitis C (69%) or B virus infection (32%) were identified. The median survival was 22 months. A raised NLR independently predicted patients' survival and was correlated with advanced Barcelona Clinic Liver Cancer stage (p = 0.003) and poor performance status (p < 0.001) but not with HIV RNA or CD4 counts. Conclusion: Systemic inflammation, as measured by NLR, is a prognostic determinant associated with adverse pathological features of malignancy, but not coexisting HIV infection, suggesting a tumour-promoting role of the innate immune response that warrants further investigation in mechanistic studies. © 2017 S. Karger AG, Basel
Original languageEnglish
Pages (from-to)395-400
Number of pages6
JournalOncology (Switzerland)
Volume93
Issue number6
DOIs
Publication statusPublished - 2017

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Pinato, DJ., Merli, M., Dalla Pria, A., Jamshaid, S., Parker, K., Pagani, N., Hasson, H., Uberti Foppa, C., Messina, E., Sharma, R., Nelson, M., & Bower, M. (2017). Systemic Inflammatory Response Is a Prognostic Marker in HIV-Infected Patients with Hepatocellular Carcinoma. Oncology (Switzerland), 93(6), 395-400. https://doi.org/10.1159/000479521