Systemic juvenile idiopathic arthritis

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic juvenile idiopathic arthritis (sJIA) sets well apart from all the other forms of JIA. Several observations show that sJIA is etiopathogenically different from all the other forms of JIA and has a prominent autoinflammatory component. A major role in the pathogenesis is played by two proinflammatory cytokines, interleukin-6 and interleukin-1. The specific inhibition of these two cytokines is going to change not only the therapeutic approach to the disease but also, presumably, its long term prognosis.

Original languageEnglish
Pages (from-to)56-59
Number of pages4
JournalAutoimmunity Reviews
Volume12
Issue number1
DOIs
Publication statusPublished - Nov 2012

Keywords

  • Interleukin 1
  • Interleukin 6
  • Still's disease
  • Systemic juvenile idiopathic arthritis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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