Systemic juvenile idiopathic arthritis (sJIA) sets well apart from all the other forms of JIA. Several observations show that sJIA is etiopathogenically different from all the other forms of JIA and has a prominent autoinflammatory component. A major role in particular is played by two proinflammatory cytokines, interleukin-6 and interleukin-1. The specific inhibition of these two cytokines is going to change not only the therapeutic approach to the disease but also, presumably, its long-term prognosis.
|Translated title of the contribution||Systemic juvenile idiopathic arthritis: New pathogenetic and therapeutic aspects|
|Number of pages||4|
|Journal||Revue du Rhumatisme Monographies|
|Publication status||Published - Feb 2012|
- Autoinflammatory disease
ASJC Scopus subject areas