Maladie de Still de l'enfant, évolution conceptuelle et thérapeutique

Alberto Martini

doi:10.1016/j.monrhu.2011.11.006

Maladie de Still de l'enfant, évolution conceptuelle et thérapeutique

Translated title of the contribution: Systemic juvenile idiopathic arthritis: New pathogenetic and therapeutic aspects

Alberto Martini

Istituto "Giannina Gaslini"

Research output: Contribution to journal › Article › peer-review

Abstract

Systemic juvenile idiopathic arthritis (sJIA) sets well apart from all the other forms of JIA. Several observations show that sJIA is etiopathogenically different from all the other forms of JIA and has a prominent autoinflammatory component. A major role in particular is played by two proinflammatory cytokines, interleukin-6 and interleukin-1. The specific inhibition of these two cytokines is going to change not only the therapeutic approach to the disease but also, presumably, its long-term prognosis.

Translated title of the contribution	Systemic juvenile idiopathic arthritis: New pathogenetic and therapeutic aspects
Original language	French
Pages (from-to)	3-6
Number of pages	4
Journal	Revue du Rhumatisme Monographies
Volume	79
Issue number	1
DOIs	https://doi.org/10.1016/j.monrhu.2011.11.006
Publication status	Published - Feb 2012

Keywords

Autoinflammatory disease
Interleukin-1
Interleukin-6

ASJC Scopus subject areas

Rheumatology

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10.1016/j.monrhu.2011.11.006

Cite this

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abstract = "Systemic juvenile idiopathic arthritis (sJIA) sets well apart from all the other forms of JIA. Several observations show that sJIA is etiopathogenically different from all the other forms of JIA and has a prominent autoinflammatory component. A major role in particular is played by two proinflammatory cytokines, interleukin-6 and interleukin-1. The specific inhibition of these two cytokines is going to change not only the therapeutic approach to the disease but also, presumably, its long-term prognosis.",

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AB - Systemic juvenile idiopathic arthritis (sJIA) sets well apart from all the other forms of JIA. Several observations show that sJIA is etiopathogenically different from all the other forms of JIA and has a prominent autoinflammatory component. A major role in particular is played by two proinflammatory cytokines, interleukin-6 and interleukin-1. The specific inhibition of these two cytokines is going to change not only the therapeutic approach to the disease but also, presumably, its long-term prognosis.

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KW - Interleukin-6

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Maladie de Still de l'enfant, évolution conceptuelle et thérapeutique

Abstract

Keywords

ASJC Scopus subject areas

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