Systemic nitroglycerin activates peptidergic and catecholaminergic pathways in rat brain

Cristina Tassorelli, Shirley A. Joseph

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In this study, we carried out an immunohistochemical evaluation of the neurochemical characteristics of neurons that are activated (i.e., express Fos protein) in response to systemic administration of nitroglycerin. In the brain stem, a significant percentage of activated neurons contained noradrenaline as a neurotransmitter, whereas only a few of them contained serotonin. In the paraventricular and supraoptic nuclei of the hypothalamus, numerous Fos-immunoreactive neurons were also positive for vasopressin, oxytocin, and corticotropin-releasing factor. Codistribution with corticotropin-releasing factor was also observed in the central nucleus of the amygdala. Our findings point out a prominent role for catecholaminergic and peptidergic pathways in the brain in response to systemic nitroglycerin.

Original languageEnglish
Pages (from-to)443-449
Number of pages7
JournalPeptides
Volume17
Issue number3
DOIs
Publication statusPublished - 1996

Fingerprint

Nitroglycerin
Neurons
Rats
Brain
Corticotropin-Releasing Hormone
Supraoptic Nucleus
Paraventricular Hypothalamic Nucleus
Oxytocin
Vasopressins
Brain Stem
Neurotransmitter Agents
Serotonin
Norepinephrine
Proteins

Keywords

  • Catecholamines
  • Corticotropin-releasing factor
  • Fos
  • Nitric oxide
  • Nitroglycerin
  • Oxytocin
  • Vasopressin

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Cellular and Molecular Neuroscience

Cite this

Systemic nitroglycerin activates peptidergic and catecholaminergic pathways in rat brain. / Tassorelli, Cristina; Joseph, Shirley A.

In: Peptides, Vol. 17, No. 3, 1996, p. 443-449.

Research output: Contribution to journalArticle

@article{a2f75c928af3446bb17d5f6175d49626,
title = "Systemic nitroglycerin activates peptidergic and catecholaminergic pathways in rat brain",
abstract = "In this study, we carried out an immunohistochemical evaluation of the neurochemical characteristics of neurons that are activated (i.e., express Fos protein) in response to systemic administration of nitroglycerin. In the brain stem, a significant percentage of activated neurons contained noradrenaline as a neurotransmitter, whereas only a few of them contained serotonin. In the paraventricular and supraoptic nuclei of the hypothalamus, numerous Fos-immunoreactive neurons were also positive for vasopressin, oxytocin, and corticotropin-releasing factor. Codistribution with corticotropin-releasing factor was also observed in the central nucleus of the amygdala. Our findings point out a prominent role for catecholaminergic and peptidergic pathways in the brain in response to systemic nitroglycerin.",
keywords = "Catecholamines, Corticotropin-releasing factor, Fos, Nitric oxide, Nitroglycerin, Oxytocin, Vasopressin",
author = "Cristina Tassorelli and Joseph, {Shirley A.}",
year = "1996",
doi = "10.1016/0196-9781(96)00005-8",
language = "English",
volume = "17",
pages = "443--449",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Systemic nitroglycerin activates peptidergic and catecholaminergic pathways in rat brain

AU - Tassorelli, Cristina

AU - Joseph, Shirley A.

PY - 1996

Y1 - 1996

N2 - In this study, we carried out an immunohistochemical evaluation of the neurochemical characteristics of neurons that are activated (i.e., express Fos protein) in response to systemic administration of nitroglycerin. In the brain stem, a significant percentage of activated neurons contained noradrenaline as a neurotransmitter, whereas only a few of them contained serotonin. In the paraventricular and supraoptic nuclei of the hypothalamus, numerous Fos-immunoreactive neurons were also positive for vasopressin, oxytocin, and corticotropin-releasing factor. Codistribution with corticotropin-releasing factor was also observed in the central nucleus of the amygdala. Our findings point out a prominent role for catecholaminergic and peptidergic pathways in the brain in response to systemic nitroglycerin.

AB - In this study, we carried out an immunohistochemical evaluation of the neurochemical characteristics of neurons that are activated (i.e., express Fos protein) in response to systemic administration of nitroglycerin. In the brain stem, a significant percentage of activated neurons contained noradrenaline as a neurotransmitter, whereas only a few of them contained serotonin. In the paraventricular and supraoptic nuclei of the hypothalamus, numerous Fos-immunoreactive neurons were also positive for vasopressin, oxytocin, and corticotropin-releasing factor. Codistribution with corticotropin-releasing factor was also observed in the central nucleus of the amygdala. Our findings point out a prominent role for catecholaminergic and peptidergic pathways in the brain in response to systemic nitroglycerin.

KW - Catecholamines

KW - Corticotropin-releasing factor

KW - Fos

KW - Nitric oxide

KW - Nitroglycerin

KW - Oxytocin

KW - Vasopressin

UR - http://www.scopus.com/inward/record.url?scp=0029975513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029975513&partnerID=8YFLogxK

U2 - 10.1016/0196-9781(96)00005-8

DO - 10.1016/0196-9781(96)00005-8

M3 - Article

C2 - 8735971

AN - SCOPUS:0029975513

VL - 17

SP - 443

EP - 449

JO - Peptides

JF - Peptides

SN - 0196-9781

IS - 3

ER -