Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment

Carlo Cervellati, Arianna Romani, Davide Seripa, Eleonora Cremonini, Cristina Bosi, Stefania Magon, Carlo M. Bergamini, Giuseppe Valacchi, Alberto Pilotto, Giovanni Zuliani

Research output: Contribution to journalArticle

Abstract

Mild cognitive impairment (MCI) is regarded as a prodromal phase of late onset Alzheimer's disease (LOAD). It has been proposed that oxidative stress (OxS) might be implicated in the pathogenesis of LOAD. The aim of this study was to investigate whether a redox imbalance measured as serum level of hydroperoxides (i.e., by-products of lipid peroxidation) and/or serum antioxidant capacity might be predictive of the clinical progression of MCI to LOAD. The levels of these two markers were measured in 111 patients with MCI (follow-up: 2.0 ± 0.6 years), 105 patients with LOAD, and 118 nondemented healthy controls. Multivariate analysis adjusted for potential confounding factors, including age, gender, smoking, and comorbidities, showed a significant increase (P <0.05) in baseline levels of OxS in MCI and LOAD as compared to cognitive healthy controls. No differences in either of OxS markers were found by comparing MCI patients who converted (n = 29) or not converted (n = 82) to LOAD. Overall, these results suggest that systemic OxS might be a precocious feature of MCI and LOAD. However, the role of OxS as an early prognostic marker of progression to LOAD needs further investigations.

Original languageEnglish
Article number309507
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Oxidative stress
Dementia
Alzheimer Disease
Oxidative Stress
Cognitive Dysfunction
Age Factors
Serum
Hydrogen Peroxide
Lipid Peroxidation
Oxidation-Reduction
Byproducts
Comorbidity
Multivariate Analysis
Antioxidants
Smoking
Lipids

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment. / Cervellati, Carlo; Romani, Arianna; Seripa, Davide; Cremonini, Eleonora; Bosi, Cristina; Magon, Stefania; Bergamini, Carlo M.; Valacchi, Giuseppe; Pilotto, Alberto; Zuliani, Giovanni.

In: BioMed Research International, Vol. 2014, 309507, 2014.

Research output: Contribution to journalArticle

Cervellati, C, Romani, A, Seripa, D, Cremonini, E, Bosi, C, Magon, S, Bergamini, CM, Valacchi, G, Pilotto, A & Zuliani, G 2014, 'Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment', BioMed Research International, vol. 2014, 309507. https://doi.org/10.1155/2014/309507
Cervellati, Carlo ; Romani, Arianna ; Seripa, Davide ; Cremonini, Eleonora ; Bosi, Cristina ; Magon, Stefania ; Bergamini, Carlo M. ; Valacchi, Giuseppe ; Pilotto, Alberto ; Zuliani, Giovanni. / Systemic oxidative stress and conversion to dementia of elderly patients with mild cognitive impairment. In: BioMed Research International. 2014 ; Vol. 2014.
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