Systemic sclerosis stimulates angiogenesis in the chick embryo chorioallantoic membrane

D. Ribatti, F. P. Cantatore, A. Vacca, M. D'Amore, R. Ria, L. Roncali, V. Pipitone

Research output: Contribution to journalArticlepeer-review

Abstract

Skin biopsies from patients with systemic sclerosis (SSc) were investigated for their angiogenic activity by using the chick embryo chorioallantoic membrane (CAM) assay. Ten samples of SSc and 10 of normal skin from age- and sex-matched subjects were grafted onto the CAM, and the angiogenic response in pathological and control implants was assessed on histological sections by a planimetric point-count method 4 days after grafting. The vascular counts in the area underlying the SSc were significantly higher than those of normal skin and a dense mononuclear cell infiltrate was detectable around the blood vessels in pathological specimens. These results suggest that SSc may promote angiogenesis, perhaps leading to the release of several angiogenic factors. Moreover, the role played in the angiogenic response by the inflammatory cells forming the cellular infiltrate is suggested by this study.

Original languageEnglish
Pages (from-to)115-120
Number of pages6
JournalClinical Rheumatology
Volume17
Issue number2
DOIs
Publication statusPublished - 1998

Keywords

  • Angiogenesis
  • Chorioallantoic membrane
  • Systemic sclerosis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

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