Systemic treatments for brain metastases from breast cancer, non-small cell lung cancer, melanoma and renal cell carcinoma: an overview of the literature.

Giuseppe Lombardi, Anna Luisa Di Stefano, Patrizia Farina, Vittorina Zagonel, Emeline Tabouret

Research output: Contribution to journalArticlepeer-review

Abstract

The frequency of metastatic brain tumors has increased over recent years; the primary tumors most involved are breast cancer, lung cancer, melanoma and renal cell carcinoma. While radiation therapy and surgery remain the mainstay treatment in selected patients, new molecular drugs have been developed for brain metastases. Studies so far report interesting results. This review focuses on systemic cytotoxic drugs and, in particular, on new targeted therapies and their clinically relevant activities in brain metastases from solid tumors in adults.

Original languageEnglish
Pages (from-to)951-959
Number of pages9
JournalCancer Treatment Reviews
Volume40
Issue number8
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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