Systemic vascular hemodynamic changes due to 17-β-estradiol intranasal administration

Marco Matteo Ciccone, Pietro Scicchitano, Michele Gesualdo, Fara Fornarelli, Vincenzo Pinto, Giuseppe Farinola, Rocco Lagioia, Marco Sassara, Annapaola Zito, Antonio Federici, Ettore Cicinelli

Research output: Contribution to journalArticlepeer-review


Purpose: According to the literature, estradiol has a direct vasodilator action by means of endothelium-derived relaxing factor synthesis. The present study aims to evaluate the acute hemodynamic effects of intranasal 17-b-estradiol on cerebral and lower limb arterial circulation in postmenopausal women. Methods: Sixteen healthy women in natural menopause (mean age: 54 + 3 years) were investigated for at least 6 months, each receiving 300 mg of intranasal 17-b-estradiol. We evaluated the heart rate, systolic/diastolic blood pressure, peak systolic velocity, end-diastolic velocity, and velocitytime integral (VTI) at the level of internal carotid and posterior tibial arteries, before and after 30, 60, and 180 minutes of drug administration. Results: After intranasal 17-b-estradiol administration, the internal carotid artery VTI showed statistically significant (P <.05) variations at all the time intervals after administration of the drug (30, 60, and 180 minutes) when compared with "time zero" (T0, ie, the speed recorded at baseline before drug administration). No significant variation was found at the posterior tibial artery. The systolic/diastolic blood pressure and heart rate did not significantly differ before and after drug administration. Conclusions: The administration of a single intranasal dose of 17-b-estradiol in healthy postmenopausal women increased cerebral perfusions, whereas the effect on peripheral circulation was much more limited.

Original languageEnglish
Pages (from-to)354-358
Number of pages5
JournalJournal of Cardiovascular Pharmacology and Therapeutics
Issue number4
Publication statusPublished - Jul 2013


  • cerebral circulation
  • estradiol
  • estrogen therapy
  • menopause
  • peripheral circulation

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Cardiology and Cardiovascular Medicine


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