Systemic vascular inflammation in abdominal aortic aneurysm patients: A contrast-enhanced PET/CT study

S. Morbelli, G. Ghigliotti, G. Spinella, C. Marini, I. Bossert, M. A. Cimmino, B. Pane, N. Rousas, G. Cittadini, M. Massollo, D. Camellino, M. Riondato, D. Palombo, C. Barisione, G. Sambuceti

Research output: Contribution to journalArticlepeer-review

Abstract

Aim. The aim of this paper was to investigate the presence of systemic vascular inflammation and its relationship with risk factors and biomarkers of systemic inflammation related to atherosclerosis in asymptomatic abdominal aortic aneurysm (AAA) patients. Methods. Thirty AAA patients and 30 age-matched controls underwent contrast-enhanced 2-deoxy-2-[18F]fluo-ro-D-glucose (FDG) PET/CT. C-reactive protein, erythrocyte sedimentation rate, white blood cell count and differential, serum fibrinogen, D-dimer and full lipid panel were also evaluated. Region of interest analyses were performed to obtain target-to-background (TBR) metabolism of aorta, subclavian, carotid, iliac arteries and AAA. CT-based arterial calcium load (CL) was evaluated. Arterial Metabolism and CL intergroup differences were tested (unpaired t-test). Linear regression analysis was performed only between blood biomarkers on one side and both TBR and ACL of the arterial districts that resulted significantly different between patients and controls on the other. In all the analyses P values

Original languageEnglish
Pages (from-to)299-309
Number of pages11
JournalQuarterly Journal of Nuclear Medicine and Molecular Imaging
Volume58
Issue number3
Publication statusPublished - Sep 1 2014

Keywords

  • Abdominal
  • Aortic aneurysm
  • Atherosclerosis
  • Positron-emission tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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