Systemic vasculitis and pregnancy: A multicenter study on maternal and neonatal outcome of 65 prospectively followed pregnancies

Micaela Fredi, Maria Grazia Lazzaroni, Chiara Tani, Véronique Ramoni, Maria Gerosa, Flora Inverardi, Paolo Sfriso, Paola Caramaschi, Laura Andreoli, Renato Alberto Sinico, Mario Motta, Andrea Lojacono, Laura Trespidi, Francesca Strigini, Antonio Brucato, Roberto Caporali, Andrea Doria, Loic Guillevin, Pier Luigi Meroni, Carlomaurizio MontecuccoMarta Mosca, Angela Tincani

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Systemic vasculitis (SV) are uncommon diseases that rarely affect women during their reproductive age; little data, mainly retrospective, is available on this topic. The aim of our study was to evaluate maternal/neonatal outcome and disease course before, during and after pregnancy. Methods: Sixty-five pregnancies in 50 women with SV were followed by a multispecialistic team in 8 institutions between 1995 and 2014. Clinical data on pregnancy, 1. year before and 1. year after delivery was retrospectively collected. The rate of pregnancy complications was compared to that of a General Obstetric Population (GOP) of 3939 women. Results: In 2 patients the diagnosis of SV was done during pregnancy; 59 out of the remaining 63 started when maternal disease was quiescent. We recorded 56 deliveries with 59 live births, 8 miscarriages and 1 fetal death. In SV, preterm, particularly early preterm (

Original languageEnglish
Pages (from-to)686-691
Number of pages6
JournalAutoimmunity Reviews
Volume14
Issue number8
DOIs
Publication statusPublished - Aug 1 2015

Keywords

  • Pregnancy
  • Systemic vasculitis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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