TY - JOUR
T1 - Systems biology of host-mycobiota interactions
T2 - Dissecting Dectin-1 and Dectin-2 signalling in immune cells with DC-ATLAS
AU - Rizzetto, Lisa
AU - De Filippo, Carlotta
AU - Rivero, Damariz
AU - Riccadonna, Samantha
AU - Beltrame, Luca
AU - Cavalieri, Duccio
PY - 2013/11
Y1 - 2013/11
N2 - Modelling the networks sustaining the fruitful coexistence between fungi and their mammalian hosts is becoming increasingly important to control emerging fungal pathogens. The C-type lectins Dectin-1 and Dectin-2 are involved in host defense mechanisms against fungal infection driving inflammatory and adaptive immune responses and complement in containing fungal burdens. Recognizing carbohydrate structures in pathogens, their engagement induces maturation of dendritic cells (DCs) into potent immuno-stimulatory cells endowed with the capacity to efficiently prime T cells. Owing to these properties, Dectin-1 and Dectin-2 agonists are currently under investigation as promising adjuvants in vaccination procedures for the treatment of fungal infection. Thus, a detailed understanding of events' cascade specifically triggered in DCs upon engagement is of great interest in translational research. Here, we summarize the current knowledge on Dectin-1 and Dectin-2 signalling in DCs highlighting similarities and differences. Detailed maps are annotated, using the Biological Connection Markup Language (BCML) data model, and stored in DC-ATLAS, a versatile resource for the interpretation of high-throughput data generated perturbing the signalling network of DCs.
AB - Modelling the networks sustaining the fruitful coexistence between fungi and their mammalian hosts is becoming increasingly important to control emerging fungal pathogens. The C-type lectins Dectin-1 and Dectin-2 are involved in host defense mechanisms against fungal infection driving inflammatory and adaptive immune responses and complement in containing fungal burdens. Recognizing carbohydrate structures in pathogens, their engagement induces maturation of dendritic cells (DCs) into potent immuno-stimulatory cells endowed with the capacity to efficiently prime T cells. Owing to these properties, Dectin-1 and Dectin-2 agonists are currently under investigation as promising adjuvants in vaccination procedures for the treatment of fungal infection. Thus, a detailed understanding of events' cascade specifically triggered in DCs upon engagement is of great interest in translational research. Here, we summarize the current knowledge on Dectin-1 and Dectin-2 signalling in DCs highlighting similarities and differences. Detailed maps are annotated, using the Biological Connection Markup Language (BCML) data model, and stored in DC-ATLAS, a versatile resource for the interpretation of high-throughput data generated perturbing the signalling network of DCs.
KW - C-type lectins
KW - Cytokines
KW - Dendritic cells
KW - Immune response
KW - Signalling pathway
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U2 - 10.1016/j.imbio.2013.07.002
DO - 10.1016/j.imbio.2013.07.002
M3 - Article
C2 - 23932568
AN - SCOPUS:84884149443
VL - 218
SP - 1428
EP - 1437
JO - Immunobiology
JF - Immunobiology
SN - 0171-2985
IS - 11
ER -