Systems biology of host-mycobiota interactions: Dissecting Dectin-1 and Dectin-2 signalling in immune cells with DC-ATLAS

Lisa Rizzetto, Carlotta De Filippo, Damariz Rivero, Samantha Riccadonna, Luca Beltrame, Duccio Cavalieri

Research output: Contribution to journalArticlepeer-review

Abstract

Modelling the networks sustaining the fruitful coexistence between fungi and their mammalian hosts is becoming increasingly important to control emerging fungal pathogens. The C-type lectins Dectin-1 and Dectin-2 are involved in host defense mechanisms against fungal infection driving inflammatory and adaptive immune responses and complement in containing fungal burdens. Recognizing carbohydrate structures in pathogens, their engagement induces maturation of dendritic cells (DCs) into potent immuno-stimulatory cells endowed with the capacity to efficiently prime T cells. Owing to these properties, Dectin-1 and Dectin-2 agonists are currently under investigation as promising adjuvants in vaccination procedures for the treatment of fungal infection. Thus, a detailed understanding of events' cascade specifically triggered in DCs upon engagement is of great interest in translational research. Here, we summarize the current knowledge on Dectin-1 and Dectin-2 signalling in DCs highlighting similarities and differences. Detailed maps are annotated, using the Biological Connection Markup Language (BCML) data model, and stored in DC-ATLAS, a versatile resource for the interpretation of high-throughput data generated perturbing the signalling network of DCs.

Original languageEnglish
Pages (from-to)1428-1437
Number of pages10
JournalImmunobiology
Volume218
Issue number11
DOIs
Publication statusPublished - Nov 2013

Keywords

  • C-type lectins
  • Cytokines
  • Dendritic cells
  • Immune response
  • Signalling pathway

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Hematology

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