Systems medicine in oncology: Signaling network modeling and new-generation decision-support systems

Silvio Parodi, Giuseppe Riccardi, Nicoletta Castagnino, Lorenzo Tortolina, Massimo Maffei, Gabriele Zoppoli, Alessio Nencioni, Alberto Ballestrero, Franco Patrone

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Two different perspectives are the main focus of this book chapter: (1) A perspective that looks to the future, with the goal of devising rational associations of targeted inhibitors against distinct altered signaling-network pathways. This goal implies a sufficiently in-depth molecular diagnosis of the personal cancer of a given patient. A sufficiently robust and extended dynamic modeling will suggest rational combinations of the abovementioned oncoprotein inhibitors. The work toward new selective drugs, in the field of medicinal chemistry, is very intensive. Rational associations of selective drug inhibitors will become progressively a more realistic goal within the next 3-5 years. Toward the possibility of an implementation in standard oncologic structures of technologically sufficiently advanced countries, new (legal) rules probably will have to be established through a consensus process, at the level of both diagnostic and therapeutic behaviors. (2) The cancer patient of today is not the patient of 5-10 years from now. How to support the choice of the most convenient (and already clinically allowed) treatment for an individual cancer patient, as of today? We will consider the present level of artificial intelligence (AI) sophistication and the continuous feeding, updating, and integration of cancer-related new data, in AI systems. We will also report briefly about one of the most important projects in this field: IBM Watson US Cancer Centers. Allowing for a temporal shift, in the long term the two perspectives should move in the same direction, with a necessary time lag between them.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages181-219
Number of pages39
Volume1386
DOIs
Publication statusPublished - Jan 1 2016

Publication series

NameMethods in Molecular Biology
Volume1386
ISSN (Print)10643745

Keywords

  • Artificial intelligence
  • Cancer genomics
  • Decision-support systems
  • IBM Watson
  • Individual cancer patient
  • New clinical trial designs
  • Oncoprotein inhibitors
  • Rational associations of targeted inhibitors
  • Signaling-network pathways
  • Systems medicine

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Parodi, S., Riccardi, G., Castagnino, N., Tortolina, L., Maffei, M., Zoppoli, G., Nencioni, A., Ballestrero, A., & Patrone, F. (2016). Systems medicine in oncology: Signaling network modeling and new-generation decision-support systems. In Methods in Molecular Biology (Vol. 1386, pp. 181-219). (Methods in Molecular Biology; Vol. 1386). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-3283-2_10