Systems medicine of inflammaging

Gastone C. Castellani, Giulia Menichetti, Paolo Garagnani, Maria Giulia Bacalini, Chiara Pirazzini, Claudio Franceschi, Sebastiano Collino, Claudia Sala, Daniel Remondini, Enrico Giampieri, Ettore Mosca, Matteo Bersanelli, Silvia Vitali, Italo Faria Do Valle, Pietro Liò, Luciano Milanesi

Research output: Contribution to journalArticle


Systems Medicine (SM) can be defined as an extension of Systems Biology (SB) to Clinical-Epidemiological disciplines through a shifting paradigm, starting from a cellular, toward a patient centered framework. According to this vision, the three pillars of SM are Biomedical hypotheses, experimental data, mainly achieved by Omics technologies and tailored computational, statistical and modeling tools. The three SM pillars are highly interconnected, and their balancing is crucial. Despite the great technological progresses producing huge amount of data (Big Data) and impressive computational facilities, the Bio-Medical hypotheses are still of primary importance. A paradigmatic example of unifying Bio-Medical theory is the concept of Inflammaging. This complex phenotype is involved in a large number of pathologies and patho-physiological processes such as aging, age-related diseases and cancer, all sharing a common inflammatory pathogenesis. This Biomedical hypothesis can be mapped into an ecological perspective capable to describe by quantitative and predictive models some experimentally observed features, such as microenvironment, niche partitioning and phenotype propagation. In this article we show how this idea can be supported by computational methods useful to successfully integrate, analyze and model large data sets, combining cross-sectional and longitudinal information on clinical, environmental and omics data of healthy subjects and patients to provide new multidimensional biomarkers capable of distinguishing between different pathological conditions, e.g. healthy versus unhealthy state, physiological versus pathological aging.

Original languageEnglish
Article numberbbv062
Pages (from-to)527-540
Number of pages14
JournalBriefings in Bioinformatics
Issue number3
Publication statusPublished - May 16 2016


  • Ecological model
  • Inflammation
  • Multi-scale
  • Multilayer networks
  • Networks
  • Propagation

ASJC Scopus subject areas

  • Molecular Biology
  • Information Systems

Fingerprint Dive into the research topics of 'Systems medicine of inflammaging'. Together they form a unique fingerprint.

  • Cite this

    Castellani, G. C., Menichetti, G., Garagnani, P., Bacalini, M. G., Pirazzini, C., Franceschi, C., Collino, S., Sala, C., Remondini, D., Giampieri, E., Mosca, E., Bersanelli, M., Vitali, S., Do Valle, I. F., Liò, P., & Milanesi, L. (2016). Systems medicine of inflammaging. Briefings in Bioinformatics, 17(3), 527-540. [bbv062].