Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risk

Michael Böhm, Helmut Schumacher, Darryl Leong, Giuseppe Mancia, Thomas Unger, Roland Schmieder, Florian Custodis, Hans Christoph Diener, Ulrich Laufs, Eva Lonn, Karen Sliwa, Koon Teo, Robert Fagard, Josep Redon, Peter Sleight, Craig Anderson, Martin O'Donnell, Salim Yusuf

Research output: Contribution to journalArticle

Abstract

Supplemental Digital Content is available in the text. Abstract - Elevated systolic blood pressure (SBP) correlates to cognitive decline and incident dementia. The effects of heart rate (HR), visit to visit HR variation, and visit to visit SBP variation are less well established. Patients without preexisting cognitive dysfunction (N=24 593) were evaluated according to mean SBP, SBP visit to visit variation (coefficient of variation [standard deviation/mean×100%], CV), mean HR, and visit to visit HR variation (HR-CV) in the Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial and the Telmisartan Randomized Assessment Study in ACE Intolerant Subjects with Cardiovascular Disease. Cognitive function was assessed with mini mental state examination. Cognitive dysfunction (fall in mini mental state examination ≤24 points), important cognitive decline (drop of ≥5 points), and cognitive deterioration (drop of >1 point per year or decline to

Original languageEnglish
Pages (from-to)651-661
Number of pages11
JournalHypertension
Volume65
Issue number3
DOIs
Publication statusPublished - Mar 4 2015

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Keywords

  • heart rate
  • hypertension
  • myocardial infarction
  • stroke

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

Böhm, M., Schumacher, H., Leong, D., Mancia, G., Unger, T., Schmieder, R., Custodis, F., Diener, H. C., Laufs, U., Lonn, E., Sliwa, K., Teo, K., Fagard, R., Redon, J., Sleight, P., Anderson, C., O'Donnell, M., & Yusuf, S. (2015). Systolic blood pressure variation and mean heart rate is associated with cognitive dysfunction in patients with high cardiovascular risk. Hypertension, 65(3), 651-661. https://doi.org/10.1161/HYPERTENSIONAHA.114.04568