SYT-SSX fusion genes and prognosis in synovial sarcoma

A. Mezzelani, L. Mariani, E. Tamborini, V. Agus, C. Riva, S. Lo Vullo, A. Fabbri, M. Stumbo, A. Azzarelli, P. G. Casali, A. Gronchi, G. Sozzi, M. A. Pierotti, S. Pilotti

Research output: Contribution to journalArticlepeer-review

Abstract

A case series of 64 synovial sarcomas was characterized for the SYT-SSX fusion transcripts and statistically analysed in order to correlate molecular data with prognosis and morphology. SYT-SSX1 fusion transcript appeared to be an independent, though not reaching statistical significance (P = 0.183), prognostic factor clearly associated with a reduced metastasis-free survival. Regarding the association between transcript type and histologic subtype we found, a borderline P value (P = 0.067) between the SYT-SSX1 transcript and the biphasic subtype which, subsequently expanding the analysis to 70 cases, turned out to be significant. However, we could not confirm the prediction value of the biphasic subtype for the presence of the SYT-SSX1 transcript since in our hands 6 out 33 (18%) biphasic tumours carried the SYT-SSX2 transcript.

Original languageEnglish
Pages (from-to)1535-1539
Number of pages5
JournalBritish Journal of Cancer
Volume85
Issue number10
DOIs
Publication statusPublished - Nov 16 2001

Keywords

  • Fusion transcripts
  • Morphology
  • Prognosis
  • Synovial sarcoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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