Tγ cell deficiency in idiopathic thrombocytopenic purpura (ITP)

F. Lauria, V. Mantovani, D. Catovsky, A. Guarini, M. Gobbi, L. Gugliotta, E. Mirone, S. Tura

Research output: Contribution to journalArticlepeer-review

Abstract

A significant reduction in the proportion and absolute number of circulating Tγ (suppressor) lymphocytes was observed in 15 adult patients with idiopathic thrombocytopenic purpura (ITP). The proportion of Tγ cells was also reduced in the spleen of four patients so investigated. This abnormality was not seen in 5 patients cured by splenectomy whilst it persisted in 3 who remained thrombocytopenic after splenectomy. The proportion of Tμ (helper) lymphocytes in ITP was normal. These findings, similar to those reported in systemic lupus erythematosus, suggest that an inbalance of the immunoregulatory T-cell subsets may be important in the pathogenesis of ITP.

Original languageEnglish
Pages (from-to)156-160
Number of pages5
JournalScandinavian Journal of Haematology
Volume26
Issue number2
Publication statusPublished - 1981

ASJC Scopus subject areas

  • Hematology

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