T and B lymphocyte subpopulations in Down's syndrome. A study on non-institutionalised subjects

C. Franceschi, F. Licastro, P. Paolucci

Research output: Contribution to journalArticle

Abstract

T and B lymphocyte subpopulations in the peripheral blood of 24 non-institutionalised Down's patients were studied. Many immunological abnormalities were found, i.e. a small significant diminution of E and EAC rosette-forming cells and a reduced thymidine uptake after in vitro stimulation with PHA, Con A and PWM at various concentrations and times of culture. These findings indicate the presence of an intrinsic immunological defect in Down's syndrome which is attributable chiefly to a defect in the T-cell compartment. The contradictory results reported in the literature about the immunological status of Down's patients and the hypothesis of a 'stress immunodeficiency' are discussed.

Original languageEnglish
Pages (from-to)179-191
Number of pages13
JournalJournal of Mental Deficiency Research
Volume22
Issue number3
Publication statusPublished - 1978

ASJC Scopus subject areas

  • Psychiatry and Mental health

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