T and B lymphocyte subpopulations in the peripheral blood of 24 non-institutionalised Down's patients were studied. Many immunological abnormalities were found, i.e. a small significant diminution of E and EAC rosette-forming cells and a reduced thymidine uptake after in vitro stimulation with PHA, Con A and PWM at various concentrations and times of culture. These findings indicate the presence of an intrinsic immunological defect in Down's syndrome which is attributable chiefly to a defect in the T-cell compartment. The contradictory results reported in the literature about the immunological status of Down's patients and the hypothesis of a 'stress immunodeficiency' are discussed.
|Number of pages||13|
|Journal||Journal of Mental Deficiency Research|
|Publication status||Published - 1978|
ASJC Scopus subject areas
- Psychiatry and Mental health