T-bet, pSTAT1 and pSTAT3 expression in peripheral blood mononuclear cells during pregnancy correlates with post-partum activation of multiple sclerosis

R. Iorio, G. Frisullo, V. Nociti, K. A. Patanella, A. Bianco, A. Marti, M. Mirabella, P. A. Tonali, A. P. Batocchi

Research output: Contribution to journalArticle

Abstract

In pregnant women affected by multiple sclerosis (MS) we observed increased percentages of CD4+CD25+Foxp3+ T regulatory cells at the 1st and the 2nd trimester of gestation that was associated with a decreased T-bet expression in CD4+ T cells. In women showing clinical relapse and/or new lesions at MRI after delivery we found, a higher expression of T-bet, pSTAT1 and pSTAT3 in CD4+, CD8+ T cells and CD14+ cells, associated with an increase of IFNγ and IL17 production by PBMC at the 3rd trimester of gestation and after delivery. Our data suggest that the expansion of circulating CD4+CD25+Foxp3+ regulatory T cells and the lower expression of T-bet in CD4+ T cells may account for the decreased MS activity during pregnancy. The expression of T-bet, pSTAT1 and pSTAT3 in peripheral blood CD4+ and CD8+ T cells and monocytes could be useful to identify MS patients who will develop a relapse after delivery.

Original languageEnglish
Pages (from-to)70-83
Number of pages14
JournalClinical Immunology
Volume131
Issue number1
DOIs
Publication statusPublished - Apr 2009

Keywords

  • Foxp3
  • Multiple sclerosis
  • Pregnancy
  • pSTAT1
  • pSTAT3
  • T regulatory cells
  • T-bet
  • Transcription factors

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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