T-cell activation and the dynamic world of rafts

Antonella Viola, Antonio Lanzavecchia

Research output: Contribution to journalArticlepeer-review

Abstract

Recent evidence, indicates that T-cell receptor (TCR) triggering and T- cell activation are dynamic processes that involve various aspects of T-cell organization. In addition to the interaction between the TCR molecule and its ligand, T-cell activation depends on a combination of many other events involving coreceptor molecules, actin cytoskeleton and plasma membrane lipids. Altogether, these cell structures organize the formation of a specialized junction between the T cell and the antigen-presenting cell (APC), that plays a critical role in sustaining and amplifying TCR signalling.

Original languageEnglish
Pages (from-to)615-623
Number of pages9
JournalAPMIS
Volume107
Issue number7
Publication statusPublished - 1999

Keywords

  • Actin cytoskeleton
  • Plasma membrane lipids
  • Rafts
  • T-cell activation
  • T-cell receptor triggering

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)
  • Immunology

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