Abstract
Recent evidence, indicates that T-cell receptor (TCR) triggering and T- cell activation are dynamic processes that involve various aspects of T-cell organization. In addition to the interaction between the TCR molecule and its ligand, T-cell activation depends on a combination of many other events involving coreceptor molecules, actin cytoskeleton and plasma membrane lipids. Altogether, these cell structures organize the formation of a specialized junction between the T cell and the antigen-presenting cell (APC), that plays a critical role in sustaining and amplifying TCR signalling.
Original language | English |
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Pages (from-to) | 615-623 |
Number of pages | 9 |
Journal | APMIS |
Volume | 107 |
Issue number | 7 |
Publication status | Published - 1999 |
Keywords
- Actin cytoskeleton
- Plasma membrane lipids
- Rafts
- T-cell activation
- T-cell receptor triggering
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Microbiology (medical)
- Immunology