Abstract
Recent evidence, indicates that T-cell receptor (TCR) triggering and T- cell activation are dynamic processes that involve various aspects of T-cell organization. In addition to the interaction between the TCR molecule and its ligand, T-cell activation depends on a combination of many other events involving coreceptor molecules, actin cytoskeleton and plasma membrane lipids. Altogether, these cell structures organize the formation of a specialized junction between the T cell and the antigen-presenting cell (APC), that plays a critical role in sustaining and amplifying TCR signalling.
| Original language | English |
|---|---|
| Pages (from-to) | 615-623 |
| Number of pages | 9 |
| Journal | APMIS |
| Volume | 107 |
| Issue number | 7 |
| Publication status | Published - 1999 |
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Keywords
- Actin cytoskeleton
- Plasma membrane lipids
- Rafts
- T-cell activation
- T-cell receptor triggering
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Microbiology (medical)
- Immunology
Cite this
T-cell activation and the dynamic world of rafts. / Viola, Antonella; Lanzavecchia, Antonio.
In: APMIS, Vol. 107, No. 7, 1999, p. 615-623.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T-cell activation and the dynamic world of rafts
AU - Viola, Antonella
AU - Lanzavecchia, Antonio
PY - 1999
Y1 - 1999
N2 - Recent evidence, indicates that T-cell receptor (TCR) triggering and T- cell activation are dynamic processes that involve various aspects of T-cell organization. In addition to the interaction between the TCR molecule and its ligand, T-cell activation depends on a combination of many other events involving coreceptor molecules, actin cytoskeleton and plasma membrane lipids. Altogether, these cell structures organize the formation of a specialized junction between the T cell and the antigen-presenting cell (APC), that plays a critical role in sustaining and amplifying TCR signalling.
AB - Recent evidence, indicates that T-cell receptor (TCR) triggering and T- cell activation are dynamic processes that involve various aspects of T-cell organization. In addition to the interaction between the TCR molecule and its ligand, T-cell activation depends on a combination of many other events involving coreceptor molecules, actin cytoskeleton and plasma membrane lipids. Altogether, these cell structures organize the formation of a specialized junction between the T cell and the antigen-presenting cell (APC), that plays a critical role in sustaining and amplifying TCR signalling.
KW - Actin cytoskeleton
KW - Plasma membrane lipids
KW - Rafts
KW - T-cell activation
KW - T-cell receptor triggering
UR - http://www.scopus.com/inward/record.url?scp=0032782603&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032782603&partnerID=8YFLogxK
M3 - Article
VL - 107
SP - 615
EP - 623
JO - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section B Microbiology
JF - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section B Microbiology
SN - 0365-5555
IS - 7
ER -