T-cell activation and the dynamic world of rafts

Antonella Viola, Antonio Lanzavecchia

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Recent evidence, indicates that T-cell receptor (TCR) triggering and T- cell activation are dynamic processes that involve various aspects of T-cell organization. In addition to the interaction between the TCR molecule and its ligand, T-cell activation depends on a combination of many other events involving coreceptor molecules, actin cytoskeleton and plasma membrane lipids. Altogether, these cell structures organize the formation of a specialized junction between the T cell and the antigen-presenting cell (APC), that plays a critical role in sustaining and amplifying TCR signalling.

Original languageEnglish
Pages (from-to)615-623
Number of pages9
JournalAPMIS
Volume107
Issue number7
Publication statusPublished - 1999

Fingerprint

T-Cell Antigen Receptor
T-Lymphocytes
Viral Tumor Antigens
Antigen-Presenting Cells
Membrane Lipids
Actin Cytoskeleton
Cell Membrane
Ligands

Keywords

  • Actin cytoskeleton
  • Plasma membrane lipids
  • Rafts
  • T-cell activation
  • T-cell receptor triggering

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Microbiology (medical)
  • Immunology

Cite this

Viola, A., & Lanzavecchia, A. (1999). T-cell activation and the dynamic world of rafts. APMIS, 107(7), 615-623.

T-cell activation and the dynamic world of rafts. / Viola, Antonella; Lanzavecchia, Antonio.

In: APMIS, Vol. 107, No. 7, 1999, p. 615-623.

Research output: Contribution to journalArticle

Viola, A & Lanzavecchia, A 1999, 'T-cell activation and the dynamic world of rafts', APMIS, vol. 107, no. 7, pp. 615-623.
Viola A, Lanzavecchia A. T-cell activation and the dynamic world of rafts. APMIS. 1999;107(7):615-623.
Viola, Antonella ; Lanzavecchia, Antonio. / T-cell activation and the dynamic world of rafts. In: APMIS. 1999 ; Vol. 107, No. 7. pp. 615-623.
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