T-cell chronic lymphocytic leukemia accounts for 1-5% of all CLL cases. The natural history of the disease has not been clearly defined because of its rarity, but clinical features and morphological and cytochemical findings can suggest a diagnosis. Moreover, in some cases leukemic T-cells retain immunoregulatory properties. In the patient herein reported immunological characterization by monoclonal antibodies allowed us to ascribe proliferating cells to T-subset with helper activity. Our results can explain some clinical and laboratory signs, such as the skin involvement and the maintenance of normal levels of immunoglobulins despite the reduction of circulating normal B-cells. Finally, possible therapeutic implications of the exact characterization of the neoplastic cells are emerging.
|Number of pages||10|
|Publication status||Published - 1982|
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