T-cell chronic lymphocytic leukemia. Report of a helper cell case

M. L. Airaghi, L. Montalbetti, B. Frigerio, G. Castiglioni, R. Invernizzi, G. Ippoliti, C. Capella

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

T-cell chronic lymphocytic leukemia accounts for 1-5% of all CLL cases. The natural history of the disease has not been clearly defined because of its rarity, but clinical features and morphological and cytochemical findings can suggest a diagnosis. Moreover, in some cases leukemic T-cells retain immunoregulatory properties. In the patient herein reported immunological characterization by monoclonal antibodies allowed us to ascribe proliferating cells to T-subset with helper activity. Our results can explain some clinical and laboratory signs, such as the skin involvement and the maintenance of normal levels of immunoglobulins despite the reduction of circulating normal B-cells. Finally, possible therapeutic implications of the exact characterization of the neoplastic cells are emerging.

Original languageEnglish
Pages (from-to)885-894
Number of pages10
JournalHaematologica
Volume67
Issue number6
Publication statusPublished - 1982

Fingerprint

T-Cell Prolymphocytic Leukemia
T-Lymphocyte Subsets
Helper-Inducer T-Lymphocytes
Immunoglobulins
B-Lymphocytes
Monoclonal Antibodies
Maintenance
T-Lymphocytes
Skin
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Airaghi, M. L., Montalbetti, L., Frigerio, B., Castiglioni, G., Invernizzi, R., Ippoliti, G., & Capella, C. (1982). T-cell chronic lymphocytic leukemia. Report of a helper cell case. Haematologica, 67(6), 885-894.

T-cell chronic lymphocytic leukemia. Report of a helper cell case. / Airaghi, M. L.; Montalbetti, L.; Frigerio, B.; Castiglioni, G.; Invernizzi, R.; Ippoliti, G.; Capella, C.

In: Haematologica, Vol. 67, No. 6, 1982, p. 885-894.

Research output: Contribution to journalArticle

Airaghi, ML, Montalbetti, L, Frigerio, B, Castiglioni, G, Invernizzi, R, Ippoliti, G & Capella, C 1982, 'T-cell chronic lymphocytic leukemia. Report of a helper cell case', Haematologica, vol. 67, no. 6, pp. 885-894.
Airaghi ML, Montalbetti L, Frigerio B, Castiglioni G, Invernizzi R, Ippoliti G et al. T-cell chronic lymphocytic leukemia. Report of a helper cell case. Haematologica. 1982;67(6):885-894.
Airaghi, M. L. ; Montalbetti, L. ; Frigerio, B. ; Castiglioni, G. ; Invernizzi, R. ; Ippoliti, G. ; Capella, C. / T-cell chronic lymphocytic leukemia. Report of a helper cell case. In: Haematologica. 1982 ; Vol. 67, No. 6. pp. 885-894.
@article{d6accbf33523461a8c9166a963b8312d,
title = "T-cell chronic lymphocytic leukemia. Report of a helper cell case",
abstract = "T-cell chronic lymphocytic leukemia accounts for 1-5{\%} of all CLL cases. The natural history of the disease has not been clearly defined because of its rarity, but clinical features and morphological and cytochemical findings can suggest a diagnosis. Moreover, in some cases leukemic T-cells retain immunoregulatory properties. In the patient herein reported immunological characterization by monoclonal antibodies allowed us to ascribe proliferating cells to T-subset with helper activity. Our results can explain some clinical and laboratory signs, such as the skin involvement and the maintenance of normal levels of immunoglobulins despite the reduction of circulating normal B-cells. Finally, possible therapeutic implications of the exact characterization of the neoplastic cells are emerging.",
author = "Airaghi, {M. L.} and L. Montalbetti and B. Frigerio and G. Castiglioni and R. Invernizzi and G. Ippoliti and C. Capella",
year = "1982",
language = "English",
volume = "67",
pages = "885--894",
journal = "Haematologica",
issn = "0390-6078",
publisher = "NLM (Medline)",
number = "6",

}

TY - JOUR

T1 - T-cell chronic lymphocytic leukemia. Report of a helper cell case

AU - Airaghi, M. L.

AU - Montalbetti, L.

AU - Frigerio, B.

AU - Castiglioni, G.

AU - Invernizzi, R.

AU - Ippoliti, G.

AU - Capella, C.

PY - 1982

Y1 - 1982

N2 - T-cell chronic lymphocytic leukemia accounts for 1-5% of all CLL cases. The natural history of the disease has not been clearly defined because of its rarity, but clinical features and morphological and cytochemical findings can suggest a diagnosis. Moreover, in some cases leukemic T-cells retain immunoregulatory properties. In the patient herein reported immunological characterization by monoclonal antibodies allowed us to ascribe proliferating cells to T-subset with helper activity. Our results can explain some clinical and laboratory signs, such as the skin involvement and the maintenance of normal levels of immunoglobulins despite the reduction of circulating normal B-cells. Finally, possible therapeutic implications of the exact characterization of the neoplastic cells are emerging.

AB - T-cell chronic lymphocytic leukemia accounts for 1-5% of all CLL cases. The natural history of the disease has not been clearly defined because of its rarity, but clinical features and morphological and cytochemical findings can suggest a diagnosis. Moreover, in some cases leukemic T-cells retain immunoregulatory properties. In the patient herein reported immunological characterization by monoclonal antibodies allowed us to ascribe proliferating cells to T-subset with helper activity. Our results can explain some clinical and laboratory signs, such as the skin involvement and the maintenance of normal levels of immunoglobulins despite the reduction of circulating normal B-cells. Finally, possible therapeutic implications of the exact characterization of the neoplastic cells are emerging.

UR - http://www.scopus.com/inward/record.url?scp=0020362933&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020362933&partnerID=8YFLogxK

M3 - Article

VL - 67

SP - 885

EP - 894

JO - Haematologica

JF - Haematologica

SN - 0390-6078

IS - 6

ER -