Abstract
Gut inflammation occurring in patients with IBDs (inflammatory bowel diseases) is associated with exaggerated and poorly controlled T-cell-mediated immune responses, which are directed against normal components of the gut flora. T-cells accumulate in the inflamed gut of IBD patients as a result of multiple mechanisms, including enhanced recruitment of cells from the bloodstream, sustained cell cycling and diminished susceptibility of cells to undergo apoptosis. Activated T-cells produce huge amounts of cytokines, which contribute to amplify and sustain the ongoing mucosal inflammation. Strategies aimed at interfering with T-cell accumulation and/or function in the gut have been employed with clinical success in patients with IBDs. In the present article, we review the available results showing that T-cell-directed therapies are useful to dampen the tissue-damaging immune response in IBDs.
| Original language | English |
|---|---|
| Pages (from-to) | 707-715 |
| Number of pages | 9 |
| Journal | Clinical Science |
| Volume | 118 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Jun 2010 |
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Keywords
- Crohn's disease
- Cytokine
- Inflammatory bowel disease (IBD)
- Interleukin
- T-cell
- Tumour necrosis factor (TNF)
- Ulcerative colitis
ASJC Scopus subject areas
- Medicine(all)
Cite this
T-cell-directed therapies in inflammatory bowel diseases. / Monteleone, Giovanni; Caprioli, Flavio.
In: Clinical Science, Vol. 118, No. 12, 06.2010, p. 707-715.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - T-cell-directed therapies in inflammatory bowel diseases
AU - Monteleone, Giovanni
AU - Caprioli, Flavio
PY - 2010/6
Y1 - 2010/6
N2 - Gut inflammation occurring in patients with IBDs (inflammatory bowel diseases) is associated with exaggerated and poorly controlled T-cell-mediated immune responses, which are directed against normal components of the gut flora. T-cells accumulate in the inflamed gut of IBD patients as a result of multiple mechanisms, including enhanced recruitment of cells from the bloodstream, sustained cell cycling and diminished susceptibility of cells to undergo apoptosis. Activated T-cells produce huge amounts of cytokines, which contribute to amplify and sustain the ongoing mucosal inflammation. Strategies aimed at interfering with T-cell accumulation and/or function in the gut have been employed with clinical success in patients with IBDs. In the present article, we review the available results showing that T-cell-directed therapies are useful to dampen the tissue-damaging immune response in IBDs.
AB - Gut inflammation occurring in patients with IBDs (inflammatory bowel diseases) is associated with exaggerated and poorly controlled T-cell-mediated immune responses, which are directed against normal components of the gut flora. T-cells accumulate in the inflamed gut of IBD patients as a result of multiple mechanisms, including enhanced recruitment of cells from the bloodstream, sustained cell cycling and diminished susceptibility of cells to undergo apoptosis. Activated T-cells produce huge amounts of cytokines, which contribute to amplify and sustain the ongoing mucosal inflammation. Strategies aimed at interfering with T-cell accumulation and/or function in the gut have been employed with clinical success in patients with IBDs. In the present article, we review the available results showing that T-cell-directed therapies are useful to dampen the tissue-damaging immune response in IBDs.
KW - Crohn's disease
KW - Cytokine
KW - Inflammatory bowel disease (IBD)
KW - Interleukin
KW - T-cell
KW - Tumour necrosis factor (TNF)
KW - Ulcerative colitis
UR - http://www.scopus.com/inward/record.url?scp=77954082347&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77954082347&partnerID=8YFLogxK
U2 - 10.1042/CS20100027
DO - 10.1042/CS20100027
M3 - Article
VL - 118
SP - 707
EP - 715
JO - Clinical Science
JF - Clinical Science
SN - 0143-5221
IS - 12
ER -